Publications

2000  1999  1998  1997  1996  1995  1994  1993  1992  1991  1990  1989  1988

2000

• Autofluorescence Patterns in Short-Term Cultures of Normal Cervical Tissue. Brookner CK, Follen M, Boiko L, Galvan J, Thomsen S, Malpica A, Suzuki S, Lotan R, and Richards-Kortum R; Photochemistry and Photobiology, 71(6): 730-736, 2000.  
  
  
• Optimal fluorescence excitation wavelengths for detection of squamous intra-epithelial neoplasia: results from an animal model Coghlan L, Utzinger U, Drezek R, Heintzelman D, Zuluaga A, Brookner C, Richards-Kortum R, Gimenez-Conti I, Follen M, Optics Express, 7(12):436-446, 2000.  
  
  
• Near Real Time Confocal Microscopy of Amelanotic Tissue: Dynamics of Aceto-whitening Enable Nuclear Segmentation. Collier T, Shen P, de Pradier B, Sung KB, Malpica A, Follen M, and Richards-Kortum R; Optics Express, Vol. 6, No. 2, 40-48, 2000.  
  
  
• A Pulsed Finite-Difference Time-Domain (FDTD) Method for Calculating Light Scattering from Cells Over Broad Wavelength Ranges. Drezek R, Dunn A, and Richards-Kortum R; Optics Express, Vol. 6, No. 7, 147-157, 2000.
  
  
• Laser scanning confocal microscopy of cervical tissue before and after application of acetic acid Drezek R, Collier T, Brookner C, Malpica A, Lotan R, Richards-Kortum R, AM J Obstet Gynecol, 182:1135-39, 2000. 
  
  
• Characterization of the Autofluorescence of Polymorphnuclear Leukocytes, Mononuclear Leukocytes and Cervical Epithelial Cancer Cells for Improved Spectroscopic Discrimination of Inflammation from Dysplasia. Heintzelman DL, Lotan R, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 71, No.3, 327-332, 2000.  
  
  
• Optimal Excitation Wavelengths for In Vivo Detection of Oral Neoplasia Using Fluorescence Spectroscopy. Heintzelman DL, Utzinger U, Fuchs H, Zuluga A, Gossage K, Gillenwater AM, Jacob R, Kemp B, and Richards-Kortum R; Photochemistry and Photobiology, 72(1): 103-113, 2000.  
  
  
• Emerging Technologies and Cervical Cancer. Follen M, and Richards-Kortum R; Journal of the National Cancer Institute, Vol. 92, No. 5, 363-365, March 2000.  
  
  
• Fiber-optic confocal microscopy using a spatial light modulator Lane PM, Dlugan ALP, Richards-Kortum R, and MacAulay CE; Optics Letters, 25(24): 1780-1782, 2000.
  

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1999

• Fluorescence Spectroscopy of the Cervix: Influence of Acetic Acid, Cervical Mucus, and Vaginal Medications Agrawal A, Utzinger U, Brookner C, Pitris C, Mitchell MF, and Richards-Kortum R; Lasers in Surgery and Medicine, Vol. 25, 237-249, 1999.  
  
  
• Report of the Advisory Council on Optical Technologies Bigio I, Shtern F, Ascher S, Andrews R, Bohorfush A, Brezinski M, Fujimoto J, Lam S, Mulshine J, Richards-Kortum R, Svanberg K, Tadir Y, and Tromberg B; Academic Radiology, Volume 6, Supplement 3, S157-S191, 1999.  
  
  
• Cervical Fluorescence of Normal Women Brookner CK, Utzinger U, Staerkel G, Ricahrds-Kortum R, and Mitchell MF; Lasers in Surgery and Medicine, Vol.24, 29-37, 1999.  
  
  
• A Comparison of C/B Ratios from Studies Using Receiver Operating Characteristic Curve Analysis. Cantor SB, Sun CC, Tortolero-Luna G, Richards-Kortum R, and Follen M; J Clin Epidemiol, Vol. 52, No. 9, 885-892, 1999.  
  
  
• Light scattering from cells: finite-difference time-domain simulations and goniometric measurements. Drezek R, Dunn A, and Ricahrds-Kortum R; Appliced Optics, Vol. 38, No. 16, 3651-3661, 1999.
  
  
• Fluorescence Spectroscopy for Diagnosis of Squamous Intraepithelial Lesions of the Cervix. Mitchell MF, Cantor SB, Ramanujam N, Tortolero-Luna G, and Richards-Kortum R; Obstetrics & Gynecology, Vol. 93, No. 3, 462-470, 1999.  
  
  
• Screening for Squamous Intraepithelial Lesions with Fluorescence Spectroscopy. Mitchell MF, Cantor SB, Brookner C, Utzinger U, Schottenfeld D, and Richards-Kortum R; Obstetrics & Gynecology, Vol. 94, No. 5, Part 2, 889-896, 1999.  
  
  
• Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morpholoy? Sokolov K, Drezek R, Gossage K, and Richards-Kortum R; Optics Express, 5(13):302-317, 1999.  
  
  
• Performance Estimation of Diagnostic Tests for Cervical Precancer Based on Fluorescence Spectroscopy: Effects of Tissue Type, Sample Size, Population, and Signal-to-Noise Ratio Utzinger U, Trujillo EV, Atkinson EN, Mitchell MF, Cantor SB, and Richards-Kortum R; IEEE Transctions on Biomedical Engineering, Vol. 46, No. 11, 1293-1303, 1999.  
  
  
• Resonance Raman Spectroscopy at 257 nm Excitation of Nomal an Malignant Cultured Breast and Cervical Cells. Yazdi Y, Ramanujam N, Lotan R, Mitchell MF, Hittelman W, and Richards-Kortum R; Applied Spectroscopy, Vol. 53, No. 1, 82-85, 1999.  
  
  
• Fluorescence Excitation Emission Matrices of Human Tissue: A System for in Vivo Measurement an Method of Data Analysis. Zuluga AF, Utzinger U, Durkin A, Fuchs H, Gillenwater A, Jacob R, Kemp B, Fan J, and Richards-Kortum R; Applied Spectroscopy, Vol. 53, No. 3, 302-311, 1999.  
  
  
• Spatially resolved spectral interferometry for determination of subsurface structure Zuluaga AF, and Richards-Kortum R; Optics Letters, Vol. 24, No. 8, 519-521, 1999.  
  
  

1998

• Cost-Effectiveness Analysis of Diagnosis and Management of Cervical Squamous Intraepithelial Lesions Cantor SB, Mitchell MF, Tortolero-Luna G, Bratka CS, Bodurka DC, and Richards-Kortum R; Obstet & Gynecology, Vol. 91, 270-277, 1998.  
  
  
• Noninvasive Diagnosis of Oral Neoplasia Based on Fluorescence Spectroscopy and Native Tissue Autofluorescene Gillenwater A, Jacob R, Ganeshappa R, Kemp B, El-Naggar AK, Palmer JL, Clayman G, Mitchell MF, and Richards-Kortum R; Arch Otolaryngol Head Neck Surgery, Vol. 124, 1251-1258, 1998.  
  
  
• Fluorescence Spectroscopy: A Technique with Potential to Improve the Early Detection of Aerodigestive Tract Neoplasia Gillenwater A, Jacob R, Richards-Kortum R; Head & Neck, Vol. 20, 556-562, 1998.  
  
  
• Development of a Fiber Optic Probe to Measure NIR Raman Spectra of Cervical Tissue In Vivo Mahadevan-Jansen A, Mitchell MF, Ramanujam N, Utzinger U, and Ricahrds-Kortum R; Photochemistry and Photobiology, Vol. 68, No. 3, 427-431, 1998. 
  
  
• Near-Infrared Raman Spectroscopy for In Vitro Detection of Cervical Precancers Mahadevan-Jansen A, Mitchell MF, Ramanujam N, Malpica A, Thomsen S, Utzinger U, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 68, No. 1, 123-132, 1998.  
  
  
• Colposcopy for the Diagnosis of Squamous Intraepithelial Lesions: A Meta-Analysis Mitchell MF, Schottenfeld D, Tortolero-Luna G, Cantor SB, and Richards-Kortum R; Obstetrics & Gynecology, Vol. 91, No. 4, 626-632, 1998.  
  
  
• Penetration depth limits of in vivo confocal reflectance imaging Smithpeter CL, Dunn AK, Welch AJ, and Richards-Kortum R; Applied Optics, Vol. 37, No. 13, 2749-2754, 1998.  
  
  
• Near Real Time Confocal Microscopy of Cultured Amelanotic Cells: Sources of Signal, Contrast Agents and Limits of Contrast Smithpeter CL, Dunn AK, Drezek R, Collier T, and Richards-Kortum R; Journal of Biomedical Optics, Vol. 3, No. 4, 429-436, 1998.  
  
  
• Method to Determine Tissue Fluorescence Efficiency in Vivo and Predict Signal-to-Noise Ratio for Spectrometers Trujillo EV, Sandison DR, Utzinger U, Ramanujam N, Mitchell MF, and Richards-Kortum R; Applied Spectroscopy, Vol. 52, No. 7, 943-951, 1998. 
  
  
• Ensembles of Radial Basis Function Networks for Spectroscopic Detection of Cervical Precancer Tumer K, Ramanujam N, Ghosh J, and Richards-Kortum R; IEEE Transctions on Biomedical Engineering, Vol. 45, No. 8, 953-961, 1998.
  

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1997

• Safety Analysis: Relative Risks of Ultraviolet Exposure from Fluorescence Spectroscopy and Colposcopy Are Comparable Brookner CK, Agrawal A, Trujillo EV, Mitchell MF, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 65, No. 6, 1020-1025, 1997.  
  
  
• Finite-Difference Time-Domain Simulation of Light Scattering from Single Cells Dunn A, Smithpeter C, Welch AJ, and Richards-Kortum R; Journal of Biomedical Optics, Vol. 2, No. 3, 262-266, 1997.  
  
  
• Raman Spectroscopy for Cancer Detection: A Review Mahadevan-Jansen A, and Richards-Kortum R; 19th International Conference- IEEE/EMBS, Oct. 30-Nov. 2, 1997.  
  
  
• Propagation of Fluorescent Light Welch AJ, Gardner C, Richards-Kortum R, Chan E, Criswell G, Pfefer J, and Warren S; Lasers in Surgery and Medicine, Vol. 21, 166-178, 1997.  
  
  

1996

• Sources of contrast in confocal reflectance imaging Dunn AK, Smithpeter C, Welch AJ, and Richards-Kortum R; Applied Optics, Vol. 35, No. 19, 3441-3446, 1996.  
  
  
• Three-Dimensional Computation of Light Scattering From Cells Dunn A and Richards-Kortum R; IEEE Journal of Selected Topics in Quantum Electronics, Vol. 2, No. 4, 898-905, 1996.  
  
  
• Application of The Method of Partial Least Squares to Determine Chromophore Concentrations from Fluorescence Spectra of Turbid Samples Drukin AJ and Richards-Kortum R; SPIE, Vol. 2678, 475-484, 1996.  
  
  
• Comparison of Methods to Determine Chromophore Concentrations From Fluorescence Spectra of Turbid Samples Durkin AJ and Richards-Kortum R; Lasers in Surgery and Medicine, Vol. 19, 75-89, 1996.  
  
  
• Raman Spectroscopy for the Detection of Cancers and Precancers Mahadevan-Jansen A and Richards-Kortum R; Journal of Biomedical Optics, Vol. 1, No. 1, 31-70, January 1996.  
  
  
• Cervical Human Papillomavirus Infection and Intraepithelial Neoplasia: a Review Mitchell MF, Tortolero-Luna G, Wrtight T, Sarkar A, Richards-Kortum R, Hong WK, Schottenfeld D; Journal of the National Cancer Institute Monographs, Vol. 21, 17-25, 1996.  
  
  
• Cervical Precancer Detection Using a Multivariate Statistical Algorithm Based on Laser-Induced Fluorescence Spectra at Multiple Excitation Wavelengths Ramanujam N, Mitchell MF, Mahadevan-Jansen A, Thomsen SL, Staerkel G, Malpica A, Wright T, Atkinson N, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 64, No. 4, 720-735, 1996.  
  
  
• Development of a Multivatirate Statistical Algorithm to Analyze Human Cervical Tisue Fluorescence Spectra AcquiredIn Vivo Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson N, and Richards-Kortum R; Lasers in Surgery and Medicine Vol. 19, 46-62, 1996.  
  
  
• Optical Spectroscopy vs. the Surgical Suite Richards-Kortum R, Mahadevan-Jansen A, and Ramanjam N; Circuits & Devices, 34-40, 1996.  
  
  
• Spectroscopic Diagnosis of Cervical Intraepithelial Neoplasia (CIN) In Vivo Using Laser-Induced Fluorescence Spectra at Multiple Excitation Wavelengths Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson N, and Richards-Kortum R; Lasers in Surgery and Medicine Vol. 19, 63-74, 1996.  
  
  
• Development of A Cost-effective Optical System for Detection of Cervical Pre-cancer Trujilo EV, Sandison D, Ramanujam N, Follen-Mitchell M, Cantor S, and Richards-Kortum R; Dept. of Electrical and Computer Engineering.
  

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1995

• Statistical Techniques for Diagnosing CIN Using Fluorescence Spectroscopy: SVD an CART Atkinson EN, Mitchell MF, Ramanujam N, and Richards-Kortum R; Journal of Cellular Biochemistry, Supplement Vol. 23, 125-130. 1995.
  
  
• Optical Techniques for the Diagnosis of Cervical Precancers: A Comparison of Raman and Fluorescence Spectroscopies. Mahadevan A, Ramanujam N, Mitchell MF, Malpica A, Thomsen S, and Richards-Kortum R; SPIE, Vol. 2388, 110-120, 1995.  
  
  
• Chemoprevention Trials and Surrogate End Point Biomarkers in the Cervix Mitchell MF, Hittelman WK, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Wharton JT, and Hong WK; Supplement to Cancer, Vol. 76, No. 10, 1956-1977, 1995.  
  
  
• Chemoprevention trials in the cervix: design, feasibility, and recruitment Mitchell MF, Hittelman WN, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Hong WK; Journal of Cellular Biochemistry - Supplement. 23:104-12, 1995  
  
  
• Prophylaxie Du Cancer Du Col Uterin: Essais De Chimioprevention Et Indicateurs Biologiques De Pronostic Mitchell MF, Hittelman WK, Nishioka K, Tortolero-Luna G, and Richards-Kortum R, Wharton JT, Hong WK; Jobgyn, Vol. 3, No. 6, 1995.  
  
  
• Laser-induced Fluorescence Microscopy of Normal Colon and Dysplasia in Colonic Adenomas: Implications for Spectroscopic Diagnosis Romer TJ, Fitzmaurice MM, Cothren RM, Richards-Kortum R, Petras R, Sivak MV, and Kramer JR; American Journal of Gastroenterology, Vol. 90, No. 1, 81-87, 1995. 
  
  
• Combined Ultrasound and Fluorescence Spectroscopy for Physico-Chemical Imaging of Atherosclerosis Warren S, Pope K, Yazdi Y, Welch AJ, Tomsen S, Johnston AL, Davis MJ, and Richards-Kortum R; IEEE Transctions on Biomedical Engineering, Vol. 42, No. 2, 121-132, 1995.
  

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1994

• Relation between flurescence spectra of dilute and turbid samples Drukin AJ, Jaikumar S, Ramanujam N, and Richards-Kortum R; Applied Optics, Vol. 33, No. 3, 414-423, 1994. 
  
  
• Fluorescence Spectroscopy of the Cervix Ramanujam N, Mahadevan A, Mitchell MF, Thomsen S, Silva E, and Richards-Kortum R; Clinical Consultations in Obstetrics and Gynecology, Vol. 6, No. 1, 62-69, 1994.
  
  
• Fluorescence Spectroscopy: A Diagnostic Tool for Cervical Intraepithelial Neoplasia (CIN) Ramanujam N, Mitchell MF, Mahadevan A, Thomensen S, Silva E, and Richards-Kortum R; Gynecologic Oncology, Vol.52, 31-38, 1994.  
  
  
• In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence Ramanujam N, Mitchell MF, Mahadevan A, Warren S, Thomsen S, Silva E, and Richards-Kortum R; Proc. natl. Acad. USA, Vol. 91, 10193-10197, 1994.  
  
  
• Description and Performance of a Fiber-Optic Confocal Fluorescence Spectrometer Richards-Kortum R, Durkin A, and Zeng J; Applied Spectroscopy, Vol. 48, No. 3, 350-355, 1994.  
  
  
• In Vivo Fluorescence Spectroscopy: Potential for Non-Ivasive, Automated Diagnosis of Cervical Intraepithelial Neoplasia and Use as a Surrogate Endpoint Biomarker. Richards-Kotrum R, Mitchell MF, Ramanujam N, Mahadevan A, and Thomsen S; Journal of Cellular Biochemistry, Vol. 19, 111-119, 1994.
  

1993

• A Characterization of The Fluorescent Properties of Circulating Human Eosinophils Barnes D, Aggarwal S, Thomsen S, Fitzmaurice M, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 58, No. 2, 297-303, 1993.  
  
  
• Optically Dilute, Absorbing, and Turbid Phantoms for Fluorescence Spectroscopy of Homogeneous and Inhomogeneous Samples Durkin AJ, Jaikumar S, and Richards-Kortum R; Applied Spectroscopy, Vol. 47, No. 12, 2114-2121, 1993.  
  
  
• Detecting Cervical Cancer. Richards-Kortum R and Follen M; pp. 38-41.  
  
  
• Study of the Fluorescence Properties of Normal and Neoplastic Human Cervical Tissue Mahadevan A, Mitchell MF, Silva E, Thomsen S, and Richards-Kortum R; Lasers in Surgery and Medicine, Vol. 13, 647-655, 1993.  
  
  

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1992

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1991

• 476 nm Excited Laser-Induced Fluorescence Spectroscopy of Human Coronary Arteries: Applications in Cardiology Richards-Kortum R, Rava RP, Fitzmaurice M, Kramer JR, and Feld MS; American Heart Journal, Vol. 122, No. 4, 1141-1150, 1991.  
  
  
• Spectroscopic Diagnosis of Colonic Dysplasia Richards-Kortum R, Rava RP, Petras RE, Fitzmaurice M, Sivak M, and Feld MS; Photochemistry and Photobiology, Vol. 53, No. 6, 777-786, 1991.
  

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1990

• Gastrointestinal Tissue Diagnosis by Laser Induced Fluorescence Spectroscopy at Endoscopy Cothren RM, Richards-Kortum RR, Sivak MV, Fitzmaurice M, Rava RP, Boyce GA, Hayes GB, Doxtader M, Blackman R, Ivanc T, Feld MS, Petras RE; 36:105-111, Gastrointestinal Endoscopy, 1990  
  
  

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1989

• A model for extraction of diagnostic information from laser induced fluorescence spectra of human artery wall Richards-Kortum R, Rava RP, Cothren R, Mehta A, Fitzmaurice M, Ratliff NB, Kramer JR, Kittrell C, Feld MS; Spectrochimica. Acta, Vol. 45, No.1:87, 1989. 
  
  
• Spectral diagnosis of atherosclerosis using an uptical fiber laser catheter Richards-Kortum R, Mehta A, Hayes G, Cothren R, Kolubayev T, Kittrell C, Ratliff NB, Kramer JR, Feld MS; American Heart Journal, Vol. 118, No. 2, pp. 381-391, 1989.  
  
  
• Alteration of Spectral Characteristics of Human Artery Wall Caused by 476-nm Laser Irradiation Chaudhry HW, Richards-Kortum R, Kolubayev T, Kittrell C, Partovi F, Kramer JR, Feld MS; Lasers in Surgery and Medicine, Vol.9, pp. 572-580, 1989.  
  
  
• Argon ion laser-excited autofluorescence in normal and atherosclerotic aorta and coronary artery: Morphologic studies Fitzmaurice M, Bordagaray JO, Engelmann G, Richards-Kortum R, Kolubayev T, Feld MS, Ratliff NB, Kramer JR; American Heart Journal, Vol. 118, pp. 1028-38, 1989.  
  
  
• An Overview of Activities at the Laser Biomedical Research Center Dasari R, Izatt J, Richards-Kortum R, Rava R, Feld M; IEEE Engineering in Medicine and Biogy Magazine, December, 1989.  
  
  
• Fluorescence spectroscopy of turbid media: Autofluorescence of the human aorta Keijzer M, Richards-Kortum R, Jacques SL, and Feld MS; Applied Optics, Vol. 28, No. 20, 4286-4292, 1989. 
  
  
• A One-Layer Model of Laser-Induced Fluorescence for Diagnosis of Disease in Human Tissue: Applications to Atherosclerosis Richards-Kortum R, Rava RP, Fitzmaurice M, Tong LL, Ratliff NB, Kramer JR, and Feld MS; IEEE Transactions of Biomedical Engineering, Vol. 36, No. 12, 1222-1232, 1989.
  

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1988

• Remote Biomedical Spectroscopic Imaging of Human Artery Wall Hoyt CC, Richards-Kortum RR, Costello B, Sacks B, Kittrell C, Ratliff NB, Kramer JR, Feld MS; Lasers in Surgery and Medicine, Vol. 8, 1-9, 1988.