Optical Spectroscopy and Imaging Laboratory: Publications

Publications

2008 2007 2006 2005 2004 2003 2002 2001
2000-1988

2009

Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging Darren Roblyer, Cristina Kurachi, Vanda Stepanek, Michelle D. Williams, Adel K. El-Naggar, J. Jack Lee, Ann M. Gillenwater, Rebecca Richards-Kortum; Cancer Prev Res (Phila Pa), 2, (5), 423-431, May 2009

Noninvasive Evaluation of Oral Lesions Using Depth-sensitive Optical Spectroscopy Richard A. Schwarz, Wen Gao, Crystal Redden Weber, Cristina Kurachi, J. Jack Lee, Adel K. El-Naggar, Rebecca Richards-Kortum and Ann M. Gillenwater; Cancer 2009;115:1669-79, April 2009

Delivery of optical contrast agents using Triton-X100, part 1: reversible permeabilization of live cells for intracellular labeling Anne L. van de Ven, Karen Adler-Storthz, Rebecca Richards-Kortum; J Biomed Opt., 14(2) 0201012, March/April 2009

Delivery of optical contrast agents using Triton-X100, part 2: enhanced mucosal permeation for the detection of cancer biomarkers Anne L. van de Ven, Karen Adler-Storthz, Rebecca Richards-Kortum; J Biomed Opt., 14(2) 0201013, March/April 2009

Fluorescence spectroscopy of oral tissue: Monte Carlo modeling with site-specific tissue properties Ina Pavlova, Crystal Redden Weber, Richard A. Schwarz, Michele Williams, Ann M. Gillenwater, Rebecca Richards-Kortum; J Biomed Opt., 14 (1), 014009, January/February 2009

Optical Molecular Imaging of Epidermal Growth Factor Receptor Expression to Improve Detection of Oral Neoplasia Nitin Nitin, Kelsey J. Rosbach, Adel El-Naggar, Michelle Williams, Ann Gillenwater and Rebecca R. Richards-Kortum; Neoplasia, 11 (6), 542-551, June 2009

Molecular imaging of glucose uptake in oral neoplasia following topical application of fluorescently labeled deoxy-glucose Nitin, N., Carlson, A. L., Muldoon, T., El-Naggar, A. K., Gillenwater, A., Richards-Kortum, R. ; Int J Cancer. 2009 Jun 1;124(11):2634-42

Head & neck optical diagnostics: vision of the future of surgery Upile, Tahwinder, et al. Head Neck Oncol. 2009 Jul 13;1(1):25

2008

The impact of inaccurate internet health information in a secondary school learning environment Kortum P, Edwards C, Richards-Kortum R; J Med Internet Res 2008, 10(2):e17

Low-cost, multimodal, portable screening system for early detection of oral cancer Rahman M, Chaturvedi P, Gillenwater AM, Rebecca Richards-Kortum; J Biomed Opt., 13(3):0305020, May-June 2008

Metal-based nanorods as molecule-specfic contrast agents for reflectance imaging in 3D tissues Javier D, Nitin N, Roblyer D, Richards-Kortum R; J of Nanophotonics, Vol. 2, 023506, Apr 2008

Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe Schwarz R, Gao W, Daye D, Williams M, Richards-Kortum R, Gillenwater A; Applied Optics, 47(6): 825-834, Feb 2008

Aptamer-targeted gold nanoparticles as a molecular-specific contrast agents for reflectance imaging Javier, D, Nitin N, Levy M, Ellington A, Richards-Kortum R; Bioconjugate Chem., 19, 1309-1312, 2008

Automated image analysis of digital colposcopy for the detection of cervical neoplasia Park S, Follen M, Milbourne A, Rhodes H, Malpica A, MacKinnon N, MacAulay C, Markey M, Richards-Kortum R; J Biomed Opt., 13(1):014029, Jan-Feb 2008

In vivo imaging of oral neoplasia using a miniaturized fiber optic confocal reflectance microscope Maitland K, Gillenwater A, Williams M, El-Naggar A, Descour M, Richards-Kortum R; Oral Oncol., 10.1016, Feb 2008

Understanding the Biological Basis of Autofluorescence Imaging for Oral Cancer Detection: High-Resolution Fluorescence Microscopy in Viable Tissue Ina Pavlova, Michelle Williams, Adel El-Naggar, Rebecca Richards-Kortum, and Ann Gillenwater; Clin Cancer Res 2008;14(8) April 15, 2008

Model-based analysis of reflectance and fluorescence spectra for in vivo detection of cervical dysplasia and cancer; Redden Weber, C., Schwarz, R. A., Atkinson, E. N., Cox, D. D., Macaulay, C., Follen, M., Richards-Kortum, R. J Biomed Opt. 2008 Nov-Dec;13(6):064016

Monte Carlo model to describe depth selective fluorescence spectra of epithelial tissue: applications for diagnosis of oral precancer Pavlova, I., Weber, C. R., Schwarz, R. A., Williams, M., El-Naggar, A., Gillenwater, A., Richards-Kortum, R. ; J Biomed Opt. 2008 Nov-Dec;13(6):064012

Optical contrast agents and imaging systems for detection and diagnosis of cancer Mark C. Pierce, David J. Javier and Rebecca Richards-Kortum; Int. J. Cancer: 123, 1979–1990 (2008)

High-resolution imaging in Barrett’s esophagus: a novel, low-cost endoscopic microscope Timothy J. Muldoon, Sharmila Anandasabapathy, Dipen Maru, Rebecca Richards-Kortum; Gastrointest Endosc. 2008 Oct;68(4):737-44

Optical imaging for cervical cancer detection: solutions for a continuing global problem Nadhi Thekkek and Rebecca Richards-Kortum; Nat Rev Cancer. 8, 725-731, Sept. 2008

Multispectral optical imaging device for in vivo detection of oral neoplasia Roblyer, D., Richards-Kortum, R., Sokolov, K., El-Naggar, A. K., Williams, M. D., Kurachi, C., Gillenwater, A. M.; J Biomed Opt. 2008 Mar-Apr;13(2):024019

Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia Shadeo, A., Chari, R., Lonergan, K. M., Pusic, A., Miller, D., Ehlen, T., Van Niekerk, D., Matisic, J., Richards-Kortum, R., Follen, M., Guillaud, M., Lam, W. L., MacAulay, C.; BMC Genomics. 2008 Feb 4;9:64

Imaging performance of a miniature integrated microendoscope Rogers, J. D., Landau, S., Tkaczyk, T. S., Descour, M. R., Rahman, M. S., Richards-Kortum, R., Karkainen, A. H., Christenson, T.; J Biomed Opt. 2008 Sep-Oct;13(5):054020

2007

Oligonucleotide-coated metallic nanoparticles as a flexible platform for molecular imaging agents Nitin N, Javier DJ, Richards-Kortum R; Bioconjug Chem., Oct. 2007
Dual-mode reflectance and fluorescence near-video-rate confocal microscope for architectural, morphological and molecular imaging of tissue Carlson AL, Coghlan LG, Gillenwater AM, Richards-Kortum RR; J Microsc., 228(Pt 1): 11-24, Oct. 2007
Confocal microscopy and molecular-specific optical contrast agents for the detection of oral neoplasia Carlson AL, Gillenwater AM, Williams MD, El-Nagger AK, Richards-Kortum; Technol Cancer Res Treat, 6(5):361-74, Oct. 2007
Fluorescence and reflectance device variability throughout the progression of a phase II clinical trial to detect and screen for cervical neoplasia using a fiber optic probe Freeberg JA, Serachitopol DM, McKinnon N, Price R, Atkinson EN, Cox DD, MacAulay C, Richards-Kortum R, Follen M, Pikkula B; J Biomed Opt., 12(3):034015, May-Jun 2007
Instrumentation as a source of variability in the application of fluorescence spectroscopic devices for detecting cervical neoplasia Pikkula BM, Shuhatovich O, Price RL, Serachitopol DM, Follen M, McKinnon N, MacAulay C, Richards-Kortum R, Lee JS, Atkinson EN, Cox DD; J Biomed Opt., 12(3):034014, May-Jun 2007
Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo Aaron J, Nitin N, Travis K, Kumar S, Collier T, Park SY, Jose-Yacaman M, Coghlan L, Follen M, Richards-Kortum R, Sokolov K; J Biomed Opt., 12(3):034007, May-Jun 2007
Real-time reflectance confocal microscopy: comparison of two-dimensional images and three-dimensional image stacks for detection of cervical precancer Collier T, Guillaud M, Follen M, Malpica A, Richards-Kortum R; J Biomed Oct., 12(2):024021, Mar-Apr 2007
A translational bioengineering course provides substantial gains in civic scientific literacy Richards-Kortum R, Buckley D, Schwarz RA, Atkinson EN, Follen M; Ann Biomed Eng, 35(8):1324-32, Apr 2007
Plasmonic nanosensors for imaging intracellular biomarkers in live cells Kumar S, Harrison N, Richards-Kortum R, Sokolov K; Nano Lett., 7(5)1338-43, Apr 2007
Light scattering from collagen fiber networks: micro-optical properties of normal and neoplastic stroma Arifler D, Pavlova I, Gillenwater A, Richards-Kortum R; Biophys J., 92(9):3260-74, Feb 2007
Molecular optical imaging of therapeutic targets of cancer Sokolov K, Nida D, Descour M, Lacy A, Levy M, Hall B, Dharmawardhane S, Ellington A, Korgel B, Richards-Kortum R; Adv Cancer Res., 96:299-344, 2007
Fiber-optic confocal microscope using a MEMS scanner and miniature objective lens Shin, H. J., Pierce, M. C., Lee, D., Ra, H., Solgaard, O., Richards-Kortum, R. Optics Express 15 (15) 9113-9122
In situ analysis of breast cancer progression in murine models using a macroscopic fluorescence Imaging system Carlson, A. L., Hoffineyer, M. R., Wall, K. M., Baugher, P. J., Richards-Kortum, R., Dharmawardhane, S. F., Lasers in Surgery and Medicine 38 (10) 928-938

High numerical aperture microendoscope objective for a fiber confocal reflectance microscope Kester, R. T., Tkaczyk, T. S., Descour, M. R., Christenson, T., Richards-Kortum, R. Optics Express 15(5) 2409-2420
Workshop on imaging science development for cancer prevention and preemption Kelloff, G. J., et al. Cancer Biomark 3 (1) 1-33, 2007
In vivo confocal microscopy and optical contrast agents Pierce, M., Nitin, N., Mayes, W., Javier, D., Follen, M., Gillenwater, A., Richards-Kortum, R., Acta Cytologica 51 (2) 265

2006

Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements Arifler D, MacAulay C, Follen M, Richards-Kortum R; J. Biomed Opt., 11(6):064027, Nov-Dec 2006
Optical Molecular Imaging for Cancer Diagnostics and Therapeutics Kumar S, Richards-Kortum R; Nanomedicine (2006), 1(1), 23-30
Calibration standards for multi-center clinical trials of fluorescence spectroscopy for in vivo diagnosis Marin NM, Follen M, Richards-Kortum R; J. Biomed Opt., 11(1):014010, Jan-Feb 2006
Real-time detection of epidermal growth factor receptor expression in fresh oral cavity biopsies using a molecular-specific contrast agent Hsu ER, Gillenwater AM, Hasan MQ, El-Naggar AK, Williams MD, Richards-Kortum R; Int. J Cancer 118, 3062-3071
Model-based analysis of clinical fluorescence spectroscopy for in vivo detection of cervical intraepithelial dysplasia Chang SK, Marin N, Follen M, Richards-Kortum R; J. Biomed Opt., 11(2):024008, Mar-Apr 2006.
Design, assembly, and optical bench testing of a high-numerical-aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy Chidley MD, Carlson KD, Richards-Kortum R, Descour MR; J. Appl. Opt., 45(11): 10 Apr 2006, 2545-2554.
Single fiber confocal microscope with a two-axis gimbaled MEMS scanner for cellular imaging Maitland KC, Shin, HJ, Ra H, Lee D, Solgaard O, Richards-Kortum R; Opt. Express, 14(19):8604, 18 Sept 2006.
Removal of ghost images by using tilted element optical systems with polynomial surfaces for aberration compenstaion Rogers JD, Tkaczyk TS, Descour MR, Karkkainen AHO, Richards-Kortum R; Opt. Letters, 31(4), Feb 15 2006, 504-506.
In situ analysis of breast cancer progression in murine models using a macroscopic fluorescence imaging system Carlson AL, Hoffmeyer MR, Wall KM, Baugher PJ, Richards-Kortum R, Dharmawardhane SF; Lasers Surg. Med., 38: 928-938 2006.

2005

An Image Model and Segmentation Algorithm for Reflectance Confocal Images of In Vivo Cervical Tissue Luck BL, Carlson KD, Bovik AC, Richards-Kortum RR; IEEE Transactions on Image Processing, Volume 14, Issue 9, Page(s):1265 - 1276, Sept. 2005.
Reflectance spectroscopy for diagnosis of epithelial precancer: model-based analysis of fiber-optic probe designs to resolve spectral information from epithelium and stroma Arifler D, Schwarz RA, Chang SK, Richards-Kortum R; Applied Optics, Volume 44, Issue 20, 4291-4305, July 2005.
Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer Chang SK, Mirabal YN, Atkinson EN, Cox D, Malpica A, Follen M, Richards-Kortum R; J Biomed Opt., 10(2):024031, Mar-Apr 2005.
Sources of scattering in cervical tissue: determination of the scattering coefficient by confocal microscopy Collier T, Follen M, Malpica A, Richards-Kortum R; Applied Optics, 44(11): 2072-2081, Apr 2005.
In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens Carlson K, Chidley M, Sung KB, Descour M, Gillenwater A, Follen M, Richards-Kortum R; Applied Optics, 44(10): 1792-1797, Apr 2005.
Multispectral digital microscopy for in vivo detection of oral neoplasia in the hamster cheek pouch model of carcinogenesis Park SY, Sokolov K, Collier T, Aaron J, Markey M, Mackinnon N, MacAulay C, Coghlan L, Milbourne A, Follen M, Richards-Kortum R; Optics Express, 13:749-762, Feb 2005.
Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue Schwarz RA, Arifler D, Chang SK, Pavlova I, Hussain IA, Mack V, Knight B, Richards-Kortum R, Gillenwater AM; Optics Letters, 30(10): 1159-1161, May 2005.
Novel algothirm of processing optical coherence tomography images for differentiation of biological tissue pathologies Turchin IV, Sergeeva EA, Dolin LS, Kamensky VA, Shakhova NM, Richards-Kortum R; J Biomed Opt., 10(6):064024, Nov-Dec 2005.
Optical technologies for cervical neoplasia: update of an NCI program project grant Follen M, Crain S, MacAulay C, Basen-Engquist K, Cantor S, Cox D, Atkinson N, MacKinnon N, Guillaud M, Richards-Kortum R; Clin. Adv. in Hema.& Onc., 3(1), Jan 2005, 41-53.

2004

Analytical Model to Describe Fluorescence Spectra of Normal and Preneoplastic Epithelial Tissue: Comparison with Monte Carlo Simulations and Clinical Measurements Chang SK, Arifler D, Drezek R, Follen M, Richards-Kortum R; Journal of Biomedical Optics, 9(3): 511-522, May/June 2004.
Detection and Diagnosis of Oral Neoplasia with an Optical Coherence Microscope Clark A. L., Gillenwater A., Alizadeh-Naderi R.,El-Naggar A. K., Richards-Kortum R.; Journal of Biomedical Optics 9(6):1271-1280, Nov/Dec 2004.
A Far-red Fluorescent Contrast Agent to Image Epidermal Growth Factor Receptor Expression Hsu E, Anslyn E, Dharmawardhane S, Alizadeh-Naderi R, Aaron J, Sokolov K, El-Naggar A, Gillenwater A, Richards-Kortum R; Photochemistry and Photobiology, 79(3): 272–279, 2004.
Confocal Microscopy for Detection of Precancerous Cervical Lesions Luck B, Carlson K, Collier T, Sung KB; IEEE Potentials, February 2004.
In vivo pathology: microendoscopy as a new endoscopic imaging modality MacAulay C., Lane P., Richards-Kortum R.; Gastrointestinal Endoscopy Clinics of North America. 14(3): 595-620, xi, 2004.
Effect of Probe Pressure on Cervical Fluorescence Spectroscopy Measurements Nath A., Rivoire K., Chang S., Cox D., Atkinson E. N., Follen M., Richards-Kortum R.; Journal of Biomedical Optics, 9(3): 523-533, May/June 2004.
A pilot study for a screening trial of cervical fluorescence spectroscopy Nath, A., Rivoire, K., Chang, S., West, L., Cantor, S. B., Basen-Engquist, K., Adler-Storthz, K., Cox, D. D., Atkinson, E. N., Staerkel, G., Macaulay, C., Richards-Kortum, R., Follen, M.; International Journal of Gynecological Cancer, 14(6): 1097-1108, Nov 2004.
Ahh...The Power of Guilt Richards-Kortum R; SWE Magazine, Winter, 2004, pp 81-82.
The Effects of Repeated Spectroscopic Pressure Measurements on Fluorescence Intensity in the Cervix Rivoire K, Nath A, Cox D, Atkinson EN, Richards-Kortum R, Follen M; American Journal of Obstetrics and Gynecology, 191(5):1606-1617, 2004.
Vision Enhancement System for Detection of Oral Cavity Neoplasia based on Autofluorescence Svistun E, Alizadeh-Naderi R, El-Naggar A, Jacob R, Gillenwater A, Richards-Kortum R; Head & Neck, 26(3):205-15, 2004.
High Resolution Reflectance Imaging in Optically Dense Tissue Phantoms with Structured-Illumination Tkaczyk T, Rahmann M, Mack V, Sokolov K, Rogers J, Richards-Kortum R, Descour M; Optics Express, 12(16): 3745-3758, Aug 2004.

2003

Light Scattering from Normal and Dysplastic Cervical Cells at Different Epithelial Depths: Finite Difference Time Domain Modeling with a Perfectly Matched Layer Boundary Condition Arifler D, Guillaud M, Carraro A, Malpica A, Follen M, Richards-Kortum R; Journal of Biomedical Optics, 8:484-494, 2003.
Cervical cancer chemoprevention, vaccines, and surrogate endpoint biomarkers Follen M, Meyskens FL Jr, Alvarez RD, Walker JL, Bell MC, Storthz KA, Sastry J, Roy K, Richards-Kortum R, Cornelison TL. Cancer. 98 (9 Suppl):2044-51, 2003 Nov 1.
Patient Distress and Satisfaction Associated with Optical Spectroscopy of the Cervix Basen-Engquist K, Shinn EH, Warneke C, de Moor C, Le T, Richards-Kortum R, and Follen M;Am J Obstet Gynecol. 2003 Oct;189(4):1136-42
Multispectral Digital Colposcopy for in vivo Detection of Cervical Cancer Benavides JM, Chang S, Park SY, MacKinnon N, MacAulay C, Milbourne A, Malpica A, Follen M, and Richards-Kortum R; Optics Express, 11:1223-36, 2003
Effects of Biographical Variables on Cervical Fluorescence Emission Spectra Brookner C, Utzinger U, Follen M, Richards-Kortum R, and Atkinson EN; Journal of Biomedical Optics, 8:479-83, 2003.
Confocal Microscopy for Real Time Detection of Oral Cavity Neoplasia Clark AL, Gillenwater A, Collier T, Alizadeh-Naderia R, El-Naggar A, Richards-Kortum R; Clinical Cancer Research, 9(13):4714-4721, 2003.
Determination of Epithelial Tissue Scattering Coefficient using Confocal Microscopy Collier T, Arifler D, Malpica A, Follen M, Richards-Kortum R; IEEE Journal of Quantum Electronics, 9(2): 307-313, 2003.
Detecting a signal from the menstrual cycle in fluorescence spectroscopy of the cervix Cox D, Chang SK, Dawood MY, Staerkel G, Utzinger U, Richards-Kortum R, and Follen M; Journal of Applied Spectroscopy,57:67-72, 2003
Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture Drezek R, Guillaud M, Collier T, Boiko I, Malpica A, Macaulay C, Follen M, Richards-Kortum R; Journal of Biomedical Optics, 8(1):7-16, 2003
Optical Imaging for the Detection of Cervical Precancers In Vivo Drezek R, Faupel M, Pitris C, Feld M, Brewer M, Richards-Kortum R, and Follen M; Cancer – Supplement, 98/9:2015-2027, 2003
Relationship Between Collagen Autofluorescence of the Human Cervix and Menopausal Status Gill E, Malpica A, Alford R, Nath AR, Follen M, Richards-Kortum R, and Ramanujam N; Photochemistry and Photobiology, 77:653-658, 2003
Formative and Summative Assessment of the IGERT Program in Optical Biomolecular Bio-Engineering at UT Austin Richards-Kortum R, Dailey M, Harris C; Journal of Engineering Education, 92(4):345-350, 2003.
Imaging Quality Assessment of Multi-modal Miniature Microscope Lee J, Rogers JD, Descour MR, Hsu E, Aaron JS, Sokolov K, and Richards-Kortum R; Optics Express, Vol. 11:1436 – 1451, 2003.
Anatomical and Biochemical Origins of Normal and Precancerous Cervical Autofluorescence Using Laser Scanning Fluorescence Confocal Microscopy Pavlova I, Sokolov K, Drezek R, Malpica A, Follen M, and Richards-Kortum R; Photochemistry and Photobiology, 77(5):550-5, 2003.
Optical Systems for In Vivo Molecular Imaging of Cancer Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, KOrgel B, Descour M, Pasqualini R, Arap W, Lam A, Richards-Kortum R; Technology in Cancer Research and Treatment, 2(5):491-504, 2003.
Real-Time Vital Optical Imaging of Precancer Using Anti-Epidermal Growth Factor Receptor Antibodies Conjugated to Gold Nanoparticles Sokolov K., Follen M., Aaron J., Pavlova I., Malpica A., Lotan R., and Richards-Kortum R.; Cancer Research, 63:1999–2004, May 1, 2003.
Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo Sung KB, Liang C, Descour M, Follen M, Malpica A, Richards-Kortum R; 11(24):3171-3181, Optics Express, 2003.
Optimal Visual Perception and Detection of Oral Cavity Neoplasia Utzinger U, Bueeler M, Oh S, Heintzelman D.L. Svistun E, Abd-El-Barr M, Gillenwater A, and Richards-Kortum R; IEEE Trans Biomed Eng, 50(3):396-9, 2003.
Fiber optic probes for biomedical optical spectroscopy Utzinger U, Richards-Kortum R; Journal of Biomedical Optics, 8(1):121-147, 2003.

2002

Fluorescence spectroscopy as biomarker in a cell culture and in a nonhuman primate model for ovarian cancer chemopreventive agents Brewer M, Utzinger U, Yang L, Atkinson EN, Satterfield W, Auersperg N, Richards-Kortum R, Follen M, and Bast R; Journal of Biomedical Optics, 7:20-26, 2002.

Fluorescence Spectroscopy for Cervical Pre-Cancer Detection: Is There Variance Across the Menstrual Cycle? Chang SK, Dawood MY, Staerkel G, Utzinger U, Richards-Kortum R, and Follen M; Journal of Biomedical Optics, in press, 2002.
Optimal Excitation Wavelengths for Discrimination of Cervical Neoplasia Chang SK, Follen M, Malpica A, Utzinger U, Staerkel G, Cox D, Atkinson EN, MacAulay C, and Richards-Kortum R; IEEE Trans BME, 49(10):1102-1111, 2002.
Near Real Time Confocal Microscopy of Amelanotic Tissue: Detection of Dysplasia in Ex-Vivo Cervical Tissue Collier T, Lacy A, Malpica A, Follen M, and Richards-Kortum R; Academic Radiology, 9:504-512, 2002.
Towards the development of miniaturized imaging systems for detection of pre-cancer Descour MR, Kärkkäinen AHO, Rogers JD, Liang C, Kilic B, Madenci E, Rantala JT, Weinstein RS, Richards-Kortum RR, Anslyn EV, and Dupuis RD; IEEE Journal of Quantum Electronics 38:122-130, 2002.
Near real-time in vivo confocal imaging of mouse mammary tumors Lacy AA, Collier T, Price JE, Dharmawardhane S, and Richards-Kortum R; Frontiers in Bioscience. 7. January 2002. f1-7.
Design of a high-numerical-aperature miniature microscope objective for endoscopic fiber confocal reflectance microscope Liang C, Sung KB, Richards-Kortum R, and Descour MR; Applied Optics, 41:4603-4610, 2002.
Variation of Fluorescence Spectroscopy during the Menstrual Cycle MacAulay C, Richards-Kortum R, Atkinson EN, Cox D, and Follen M; submitted to Optics Express, 2002.
Reflectance spectroscopy for in vivo detection of cervical precancer Mirabal YN, Chang SK, Atkinson EN, Malpica A, Follen M, and Richards-Kortum R; Journal of Biomedical Optics 7(4):587-594, 2002.
Fiber optic probe for polarized reflectance spectroscopy in vivo: Design and performance Myakov A, Nieman L, Wicky L, Utzinger U, Richards-Kortum R, and Sokolov K; Journal of Biomedical Optics, 7(3):388-97, 2002.
Endoscopic Microscopy Sokolov K, Sung KB, Collier T, Clark A, Arifler D, Lacy A, Descour M, Richards-Kortum R; Disease Markers, 18(5,6): 269-292, 2002.
Optical spectroscopy for detection of neoplasia Sokolov K, Follen M, and Richards-Kortum R; Current Opinion in Chemical Biology 6:651-658, 2002.
Realistic three-dimensional epithelial tissue phantoms for biomedical optics Sokolov K, Galvan J, Myakov A, Lacy A, Lotan R, and Richards-Kortum R; The Journal of Biomedical Optics, 7:148-156, 2002.
Fiber-Optic Confocal Reflectance Microscope with Miniature Objective for In Vivo Imaging of Human Tissues Sung K, Liang C, Descour M, Collier T, Follen M, and Richards-Kortum R; IEEE Trans BME, 49:1168-1172, 2002.
Near real time in vivo fiber optic confocal microscopy: sub-cellular structure resolved Sung KB, Liang C, Descour M, Collier T, Follen M, and Richards-Kortum R; J Micros, 207(2):137-145, 2002.
Contrast agents for confocal microscopy: how simple chemicals affect confocal images of normal and cancer cells in suspension Zuluaga AF, Drezek R, Collier T, Lotan R, Follen M, and Richards-Kortum R; The Journal of Biomedical Optics, 7:398-403, 2002.

2001

Biomarker Modulation in a Nonhuman Rhesus Primate Model for Ovarian Cancer Chemoprevention Brewer M, Utzinger U, Satterfield W, Gershensen D, Bast R, Richards-Kortum R, and Follen M; Cancer Epidemiology, Biomakers & Prevention, 10(8):889-93, 2001.
Fluorescence Spectroscopy for In Vivo Characterization of Ovarian Tissue Brewer M, Utzinger U, Silva E, Gershenson D, Bast RC, Follen M, and Richards-Kortum R; Lasers in Surgery and Medicine, 29:128-135, 2001.
Fluorescence Spectroscopy of Epithelial Tissue Throughout the Dysplasia-Carcinoma Sequence in an Animal Model: Spectroscopic Changes Precede Morphologic Changes Coghlan L, Utzinger U, Richards-Kortum R, Brookner C, Zuluaga A, Gimeniz-Conti I, Follen M; Lasers in Surgery and Medicine 29:1-10, 2001.
Near Real-Time Confocal Microscopy of Amelanotic Tissue: Detection of Dysplasia in ex Vivo Cervical Tissue Collier T, Lacy A, Malpica A, Follen M, and Richards-Kortum R; Academic Radiology, 9:504-512, 2001.
Autofluorescence Microscopy of Fresh Cervical-Tissue Sections Reveals Alterations in Tissue Biochemistry with Dysplasia Drezek R, Brookner C, Pavlova I, Boiko I, Malpica A, Lotan R, Follen M, and Richards-Kortum R; Photochemistry and Photobiology, 73(6):636-41, 2001.
Understanding the Contributions of NADH and collagen to cervical tissue fluorescence spectra: Modeling, measurements, and implications Drezek R, Sokolov K, Utzinger U, Boiko I, Malpica A, Follen M, and Richards-Kortum R; Journal Biomedical Optics, 6(4): 385-396, 2001.
Near Real-Time In Vivo Confocal Imaging of Mouse Mammary Tumors Lacy Alicia A, Collier Tom, Price Janet E, Dharmawardhane Su, and Richards-Kortum Rebecca.
Fiber confocal reflectance microscope (FCRM) for in-vivo imaging Liang C, Sung K, Richards-Kortum R, and Descour MR; Optics Express, 9(13):821-830, 2001.
Fast and Noninvasive Fluorescence Imaging of Biologic Tissues In Vivo Using a Flying-Spot Scanner Ramanujam N, Chen J, Gossage K, Richards-Kortum R, and Chance B; IEEE Transactions on Biomedical Engineering, 48(9):1034-,1041 2001.
Low temperature fluorescence imaging of freeze-trapped human cervical tissues Ramanujam N, Richards-Kortum R, Thomsen S, Mahadevan-Jansen A, Follen M, and Chance B; Optics Express. Vol. 8, No. 6, 335-343, 2001
Near real time in vivo fiber optic confocal microscopy: sub-cellular structure resolved Sung KB, Liang C, Descour M, Collier T, Follen M, and Richards-Kortum R; Journal of Microscopy, 207(2):137-145, 2001.
Near-Infrared Raman Spectroscopy for in Vivo Detection of Cervical Precancers Utzinger U, Heintzelman DL, Mahadevan-Jansen A, Malpica A, Follen M, and Richards-Kortum R; Applied Spectroscopy, 55(8):955-959, 2001.
Reflectance Spectroscopy for In Vivo Characterization of Ovarian Tissue Utzinger U, Brewer M, Silva E, Gershensen D, Bast R, Follen Mitchell M, and Richards-Kortum R; Lasers in Surgery and Medicine, Vol. 28, 56-66, 2001.