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Supramolecular Biophysics and Bioengineering
Research groups in the area of supramolecular biophysics and bioengineering are aimed at elucidating the underlying design principles that govern the behavior of macromolecular complexes and interacting networks of proteins. Multi-component complexes of biological macromolecules form the basis of many cellular processes, including signaling, motility, metabolism, and biomolecular transport. The improper function of these supramolecular assembles has been linked to a variety of physiological disorders and diseases. We are developing detailed physical models as well as new computational and experimental methodologies that provide unique windows into how biological macromolecules self-assemble, interact, and function collectively. Our efforts are essential to developing a system-level understanding of increasingly complex biomolecular processes, and will create new avenues to predict, control, and manipulate biomolecular machinery at an integrated level.
Researchers in the Rice Department of Bioengineering that are involved in this field include:
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