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Training in Biomedical Discovery From Large Scale Data Sets Directory
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Boerwinkle, Eric
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Professor
School of Public Health
UT Health Science Center at Houston
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Email
713-500-9800
Website
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Human genetics; epidemiology; heart disease; lipid metabolism; apolipoprotein genes; DNA variation. The objective of research in this laboratory is to understand the role of individual genes in complex physiological systems characterized by gene-gene and gene-environment interactions. The model system used is lipid metabolism and its contribution to atherosclerosis. This laboratory also has experience in typing and characterizing DNA variation in highly repetitive and polymorphic VNTR loci.
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Chen, Rui
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Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
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Email
(713) 798-5194
Website
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Functional genomics of visual system development and diseases; High throughput technology; Bioinformatics
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Chiu, Wah
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6985
Website
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Structural and Computational Biology of Biological Machines; Biological applications include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Dr. Chiu has been a leading investigator in the development of electron cryomicroscopy to solve structures of macromolecular assemblies at increasingly high resolutions. Computationally, his group has developed single particle reconstruction software, which has been widely adopted by other investigators. He directs an NIH supported center (http://ncmi.bcm.edu). Among many structures his group has done, Chiu is pursuing the structural studies of viruses including herpes simplex virus, bacteriophages andVenezuelan equine encephalitis virus. His approach includes single particle and tomographic electron cryomicroscopy.
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Clark, Jr. , John W.
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Professor
Elec & Comp Engineering
Rice University
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Email
713-348-3597
Website
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Biological Systems Modeling, Medical Electronics
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Coombes, Kevin
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Research Associate Professor
Biostatistics
UT M. D. Anderson Cancer Center
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Email
713-794-4154
Website
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Analysis of microarray data; Development of programming tools for bioinformatics; Multivariable calculus; Applications of differential equations in computing
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Cox, Steven J
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Professor
Comp & Applied Mathematics
Rice University
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Email
713-348-5192
Website
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inference of material properties from electrical and optical recordings from single nerve cells
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Davis, Ronald L.
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Professor/R. P. Doherty-Welch Chair in Science
Department of Molecular and Cellular Biology
Baylor College of Medicine
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Email
713-798-6641
Website
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We study genes that have known or suspected roles in learning and memory processes.
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Dubinsky, William
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Professor
Integrative Biology & Pharm
UT Health Science Center at Houston
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Email
+1 (713) 500-63
Website
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Ethun, Karen
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Executive Director, Keck Center
GCC/Keck Center
Gulf Coast Consortia
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Email
713-348-4753
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GCC/Keck Center Programs
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Fofanov, Yuriy
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Assistant Professor
Computer Sciences
University of Houston
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Email
713-743-8553
Website
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Causality in genetic networks; Microarray technology; Gene/Protein expression; Sequence analysis; Structural identification of nonlinear dependencies; Mathematical methods of discovering non-linear conformities in experimental data; Informativity and planning of experiments on discovering nonlinear regularity
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Gao, Xiaolian
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Professor
Chemistry
University of Houston
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Email
713-743-2805
Website
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Biophysical and organic chemistry; Research in the laboratory is at the interfaces of chemistry and biological sciences. Our work focuses on two areas: (1) Biological NMR of nucleic acids, proteins, and their complexes with ligand molecules. (2) Microarray BIOCHIP technologies in synthesis and applications.
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Gibbs , Richard
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Professor
Human Genome Sequencing Center
Baylor College of Medicine
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Email
713-798-6539
Website
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The Human Genome Project; molecular basis of human genetic diseases; molecular evolution.
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Graur, Dan
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John and Rebecca Moores Professor
Department of Biology & Biochemistry
University of Houston
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Email
713-743-7236
Website
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Molecular Evolution, Phylogenetic Methodology, Patterns of Protein Evolution, Patterns of Pseudogene Evolution, Detection of Selection, Phylogeny and Evolution of Mammalian Orders and Suborders, Societal Aspects of Genetics, Genetic Engineering and Eugenics
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Guerra, Rudy
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Associate Professor
Statistics
Rice University
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Email
713-348-5453
Website
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I am generally interested in biological problems with an emphasis in biomedical research
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Hancock, John
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Professor and Chairman
Integrative Biology and Pharmacology
UT Health Science Center at Houston
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Email
Website
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Plasma Membrane Microstructure and Signal Transduction
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Jackson, Amy
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Assistant Director, Grant Programs
Keck Center
Gulf Coast Consortia
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Email
713-348-4752
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Amy manages the following GCC/Keck Center Training Programs: AHRQ Patient Safety, Biomedical Discovery Training Program, HAMBP, Theoretical and Computational Neuroscience Training Program, NSF REU.
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Kakadiaris, Ioannis
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Professor
Computer Science
University of Houston
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Email
713-743-1255
Website
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Biomedical image analysis, modeling, and simulation; Computational biomedicine; Computer vision; Pattern recognition
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Kavraki , Lydia
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Noah Harding Professor of Computer Science & Professor of Bioengineering
Computer Science and Bioengineering
Rice University
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Email
713-348-5737
Website
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Kavraki's group develops computational tools on high-performance systems to model protein structure and function, understand biomolecular interactions and help analyze, in the long run, the molecular machinery of the cell. This is done by integrating sequence information with three-dimensional structural information to capture, represent and exploit relevant molecular motion. Of particular interest are the identification of three-dimensional functional motifs in protein databases, docking of flexible molecules to flexible receptors, computer-assisted drug discovery, and the understanding and compact representation of structural changes in large biomolecular machines.
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Kimmel, Marek
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Professor
Statistics
Rice University
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Email
713-348-5255
Website
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Informatics and statistical modeling of genome dynamics
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Kohn, Hans
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Assistant Professor
Institute of Biosciences and Bioengineering
Rice University
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Email
(713) 348-3779
Website
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Evolutionary biology, genomics, population genetics, conservation genetics, medical genetics
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Lau, Ching C.
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Associate Professor
Pediatrics
Baylor College of Medicine
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Email
713-798-4543
Website
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molecular biology of pediatric brain and bone tumors and the clinical applications of genomic technologies.
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Lichtarge, Olivier
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Professor
Molecular & Human Genetics
Baylor College of Medicine
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Email
713-798-5646
Website
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Protein functional surfaces; assembly of active complexes
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Ludtke, Steve
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Associate Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6989
Website
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My work involves the 3D reconstruction of molecules and macromolecules using a technique called single particle reconstruction. My most significant contribution to the field is the development of the EMAN software package (see below), which performs semi-automated processing of individual molecule images to produce accurate 3D reconstructions.
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Ma , Jianpeng
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Associate Professor
Bioengineering
Rice University
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Email
713-348-5713
Website
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Simulation of supermolecular complexes; computer-aided drug-design. Our group is using combined experimental and computational methods to study the fusion mechanisms of influenza virus, especially the hemagglutinin-mediated cell membrane fusion. Of particular interest is to derive structural information for intermediates along the pH-triggered conformational transition, which is an extremely difficult problem. We will employ a suite of biophysical techniques including various imagining methods and computer simulation techniques.
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Mancini, Michael A.
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Associate Professor
Cell Biology
Baylor College of Medicine
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Email
713-798-8952
Website
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Functional relationship(s) between dynamic nuclear organization and transcription
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Milosavljevic, Aleksandar
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Associate Professor
Human Genome Sequencing Center
Baylor College of Medicine
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Email
713-798-8719
Website
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Bioinformatics and Comparative Genomics. Pooled Genomic Indexing (PGI). In a first genome-scale application of PGI, our lab is mapping a whole-genome BAC library of rhesus macaque onto human genomic sequence. Clone-Array Pooled Shotgun Sequencing (CAPSS). Comparative Sequence Assembly. We are further refining and applying methods and software for comparative assembly on the scale of mammalian genomes. Genome-scale Sequence Comparison Methods. One of our goals is to enable comparison of genomes at arbitrary levels of sequence assembly and to enable comparative assembly of shotgun fragments. Genboree (http://www.genboree.org). Genboree is an ¿electronic whiteboard¿ for sharing and development of sequence assemblies and annotations.
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Morrisett , Joel
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Professor
Medicine Athero & Lipo
Baylor College of Medicine
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Email
713-798-4164
Website
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Imaging, Genomics, and Proteomics of Human Atherosclerosis; elucidating the mechanism(s) whereby Lp[a] exerts its atherogenic effects; The apo[a] protein; Peptide segmenets found in the proline-rich motif of cytokine receptors are under study using the techniques of molecular modeling, circular dichroism, and nuclear magnetic resonance spetroscopy.
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Nakhleh, Luay
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Assistant Professor
Computer Science
Rice University
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Email
713-348-3959
Website
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Bioinformatics and computational biology. In this area I work on reticulate evolution, multi-locus genotype-phenotype inference, and biological signaling networks. Historical linguistics. In this area, I work on developing computational methods for reconstructing the evolution of natural languages and detecting borrowing among them.
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Palzkill, Timothy
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Chair and Professor
Pharmacology
Baylor College of Medicine
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Email
713-798-5609
Website
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Molecular Basis of Antibiotic Resistance, Functional Genomics of Bacterial Pathogens
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Penczek, Pawel
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Associate Professor
Biochemistry and Molecular Biology
UT Health Science Center at Houston
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Email
713-500-5416
Website
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We are interested in the determination of three-dimensional structures of large macromolecular complexes with low or non-existing symmetry in single-particle form using stain and cryo-electron microscopy (cryo-EM) and computer image processing techniques.
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Queller, David C.
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Professor
Ecology & Evolutionary Biology
Rice University
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Email
713-348-5220
Website
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Evolutionary Biology: I work on both theoretical and empirical aspects of the evolution of social interactions, including both sexual selection and kin selection. Recent theoretical studies have focused on generalizing inclusive fitness theory, the role of relatedness in viscous populations, and the importance of demographic advantages in the evolution of sociality in insects.
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Ram, Prahlad
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Assistant Professor
Systems Biology
UT M. D. Anderson Cancer Center
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Email
713/563-4227
Website
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Signal transduction; signaling networks; computational modeling; tartgeted molecular therapeutics; proteomics; cancer biology. We are addressing this issue in breast cancer cells using the EGFR/ErbB2 signaling network as our in silico and in vitro model system. Single nucelotide polymorphisms in MC1R receptor is a high risk factor for the development of melanoma. We are studying the possible mechanism underlying this observation.
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Shaulsky, Gadi
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Associate Professor
Mol. & Human Gen. Shaulsky
Baylor College of Medicine
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Email
713-798-8082
Website
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Genetics and Functional Genomics of Dictyostelium Development
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Strassmann , Joan E
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Professor; Department Chair
Ecology & Evolutionary Biology
Rice University
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Email
713-348-4922
Website
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Evolutionary biology, particularly social evolution and genetic conflicts of interest in social insects and social amoebae
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Subramanian , Devika
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Professor
Computer Science
Rice University
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Email
713-348-5661
Website
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Computational Biology, Conflict forecasting, Adaptive compilers, Machine learning, artificial intelligence, hybrid control, bioinformatics, cognitive science
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Wang, Jue
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Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
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Email
(713) 798-8182
Website
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Regulation of DNA replication and maintenance of genomic stability in bacteria
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Warren , Joe D
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Professor
Computer Science
Rice University
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Email
713-348-5728
Website
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algebraic geometry, computer-aided geometric design, mesh generation, symbolic computation, visualization, subdivision , wavelets
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Wensel, Theodore G
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6994
Website
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Structure and Dynamics of Signal Transducing Membranes
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