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W. M. Keck Computational Biology Training Program Directory
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Bernstam, Elmer V.
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Associate Professor of Health Informatics
School of Health Information Sciences
UT Health Science Center at Houston
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Email
713-500-3927
Website
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Shareable executable clinical practice guidelines; consumer health informatics; MEDLINE searching (Medline Query-By-Example), informatics in clinical and translational research
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Boerwinkle, Eric
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Professor
School of Public Health
UT Health Science Center at Houston
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Email
713-500-9800
Website
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Human genetics; epidemiology; heart disease; lipid metabolism; apolipoprotein genes; DNA variation. The objective of research in this laboratory is to understand the role of individual genes in complex physiological systems characterized by gene-gene and gene-environment interactions. The model system used is lipid metabolism and its contribution to atherosclerosis. This laboratory also has experience in typing and characterizing DNA variation in highly repetitive and polymorphic VNTR loci.
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Chiu, Wah
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6985
Website
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Structural and Computational Biology of Biological Machines; Biological applications include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Dr. Chiu has been a leading investigator in the development of electron cryomicroscopy to solve structures of macromolecular assemblies at increasingly high resolutions. Computationally, his group has developed single particle reconstruction software, which has been widely adopted by other investigators. He directs an NIH supported center (http://ncmi.bcm.edu). Among many structures his group has done, Chiu is pursuing the structural studies of viruses including herpes simplex virus, bacteriophages andVenezuelan equine encephalitis virus. His approach includes single particle and tomographic electron cryomicroscopy.
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Cooney, Austin
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Assistant Professor
Cell Biology
Baylor College of Medicine
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Email
713-790-1275
Website
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Regulation of gene expression by orphan nuclear receptors
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Cox, Steven J
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Professor
Comp & Applied Mathematics
Rice University
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Email
713-348-5192
Website
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inference of material properties from electrical and optical recordings from single nerve cells
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Fofanov, Yuriy
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Assistant Professor
Computer Sciences
University of Houston
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Email
713-743-8553
Website
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Causality in genetic networks; Microarray technology; Gene/Protein expression; Sequence analysis; Structural identification of nonlinear dependencies; Mathematical methods of discovering non-linear conformities in experimental data; Informativity and planning of experiments on discovering nonlinear regularity
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Fox, George E.
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Professor
Biology and Biochemistry
University of Houston
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Email
713-743-8363
Website
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Molecular Evolution, Bioinformatics, RNA structure and Evolution, Origin of Life, Environmental Monitoring, Molecular Biology, Array Hybridization; Protein folding, genomics, proteomics and systems biology
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Fox , Robert O.
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Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
409-772-2163
Website
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Our laboratory investigates the structural basis of macromolecular interactions using a variety of biophysical tools including X-ray crystallography and NMR spectroscopy. The general goal of our laboratory is to determine the manner in which amino acid sequence information promotes the formation of stable folded globular protein molecules and modulates the affinity and specificity of protein ligand interactions. We use molecular genetic tools to produce variant protein molecules for characterization by biophysical methods.
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Goldman, Ronald
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Professor
Computer Science
Rice University
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Email
713-348-5729
Website
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My current research interests lie in the mathematical representation, manipulation, and analysis of shape using computers. I am particularly interested in algorithms for polynomial and piecewise polynomial curves and surfaces, and I have investigated both parametrically and implicitly represented geometry. My current work includes research in computer aided geometric design, solid modeling, computer graphics, and splines.
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Guerra, Rudy
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Associate Professor
Statistics
Rice University
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Email
713-348-5453
Website
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I am generally interested in biological problems with an emphasis in biomedical research
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Hilser, Vincent
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Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
409-747-6813
Website
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Research in our lab is focused on the experimental characterization of conformational fluctuations, the development and refinement of a general ensemble-based model for fluctuations, and the projection of this thermodynamic model into genomic analysis. Our goals are to unify the description of protein behaviors in such a way as to understand their relationships at the phenomenological level, to codify these relationships in a simple structure-based model, and to apply our model to a number of experimental systems that can be used to test and refine our approach.
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Johnsson, Lennart
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Cullen Distinguished Professor
Computer Sciences
University of Houston
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Email
713-743-3371
Website
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Computational and data grids
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Kakadiaris, Ioannis
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Professor
Computer Science
University of Houston
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Email
713-743-1255
Website
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Biomedical image analysis, modeling, and simulation; Computational biomedicine; Computer vision; Pattern recognition
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Kavraki , Lydia
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Noah Harding Professor of Computer Science & Professor of Bioengineering
Computer Science and Bioengineering
Rice University
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Email
713-348-5737
Website
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Kavraki's group develops computational tools on high-performance systems to model protein structure and function, understand biomolecular interactions and help analyze, in the long run, the molecular machinery of the cell. This is done by integrating sequence information with three-dimensional structural information to capture, represent and exploit relevant molecular motion. Of particular interest are the identification of three-dimensional functional motifs in protein databases, docking of flexible molecules to flexible receptors, computer-assisted drug discovery, and the understanding and compact representation of structural changes in large biomolecular machines.
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Kimmel, Marek
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Professor
Statistics
Rice University
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Email
713-348-5255
Website
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Informatics and statistical modeling of genome dynamics
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Lichtarge, Olivier
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Professor
Molecular & Human Genetics
Baylor College of Medicine
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Email
713-798-5646
Website
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Protein functional surfaces; assembly of active complexes
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Ma , Jianpeng
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Associate Professor
Bioengineering
Rice University
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Email
713-348-5713
Website
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Simulation of supermolecular complexes; computer-aided drug-design. Our group is using combined experimental and computational methods to study the fusion mechanisms of influenza virus, especially the hemagglutinin-mediated cell membrane fusion. Of particular interest is to derive structural information for intermediates along the pH-triggered conformational transition, which is an extremely difficult problem. We will employ a suite of biophysical techniques including various imagining methods and computer simulation techniques.
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MacKenzie , Kevin R
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Assistant Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-2228
Website
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Structure and stability of membrane proteins
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Milosavljevic, Aleksandar
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Associate Professor
Human Genome Sequencing Center
Baylor College of Medicine
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Email
713-798-8719
Website
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Bioinformatics and Comparative Genomics. Pooled Genomic Indexing (PGI). In a first genome-scale application of PGI, our lab is mapping a whole-genome BAC library of rhesus macaque onto human genomic sequence. Clone-Array Pooled Shotgun Sequencing (CAPSS). Comparative Sequence Assembly. We are further refining and applying methods and software for comparative assembly on the scale of mammalian genomes. Genome-scale Sequence Comparison Methods. One of our goals is to enable comparison of genomes at arbitrary levels of sequence assembly and to enable comparative assembly of shotgun fragments. Genboree (http://www.genboree.org). Genboree is an ¿electronic whiteboard¿ for sharing and development of sequence assemblies and annotations.
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Pettitt, B. Monte
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Cullen Distinguished Professor
Chemistry
University of Houston
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Email
713-743-3263
Website
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Chemical physics; Physical chemistry; Biochemistry; Computer Science; Development of methods for calculating internal conformational structure and interpreting conformational equilibria of biomolecular solutes in aqueous environments; Structural and thermodynamic description of neat polar molecular fluids, including water, ions, polar biomolecular solutes and other condensed phase systems via integral equation and density functional methods; Development of theoretical techniques for the description of the thermodynamics and structure of ionic and anisotropic fluids; Development of methods to compare and search genomes
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Quiocho, Florante
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Professor
Hhmi Biochemistry
Baylor College of Medicine
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Email
713-798-6565
Website
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Structural Biophysics and Biology; X-Ray Crystallography of Proteins; Molecular Recognition and Protein-Ligand Interactions. Our research interest is centered on the study of the tertiary structure and function of proteins and enzymes at atomic resolution.
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Shamoo , Yousif
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Associate Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-5493
Website
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sequence-specic RNA recognition, DNA replication and molecular evolution of microbial populations
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Shaulsky, Gadi
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Associate Professor
Mol. & Human Gen. Shaulsky
Baylor College of Medicine
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Email
713-798-8082
Website
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Genetics and Functional Genomics of Dictyostelium Development
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Smith, Jack W.
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Dean & Professor
School of Health Information Sciences
UT Health Science Center at Houston
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Email
713-500-3925
Website
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Artificial intelligence, modeling problem-solving in healthcare, implementation of decision support and tutoring systems, modeling complex human problem-solving, application of cognitive science to understanding, human-computer interaction
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Thompson, Edward Bradley
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Professor and Chair
Biochemistry & Molecular Biology
UT Medical Branch at Galveston
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Email
409-772-3367
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This laboratory has a longstanding interest in the cellular and molecular actions of steroids, especially glucocorticoids and oxysterols.
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Wang, Hongbin
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Associate Professor
School of Health Information Sciences
UT Health Science Center at Houston
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Email
713-500-3911
Website
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Spatial cognition; Medical decision making abductive/diagnostic reasoning; Human machine learning; Computational modeling; Human-computer interaction
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Warren , Joe D
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Professor
Computer Science
Rice University
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Email
713-348-5728
Website
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algebraic geometry, computer-aided geometric design, mesh generation, symbolic computation, visualization, subdivision , wavelets
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Wensel, Theodore G
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6994
Website
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Structure and Dynamics of Signal Transducing Membranes
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Zhang, Jiajie
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Associate Dean for Research & Professor
School of Health Information Sciences
UT Health Science Center at Houston
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Email
713-500-3922
Website
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Biomedical informatics, electronic health records, human-centered computing, cognitive science in medicine, information display and visualization, medical error, decision making
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Zouridakis, George
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Associate Professor, Director Biomedical Imaging Lab
Computer Sciences
University of Houston
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Email
713-743-8656
Website
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Biomedical Imaging, Computational Biomedicine, Functional Brain Mapping, Biosignal Analysis and Modeling
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