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Nanobiology Training Program Directory
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Advincula, Rigoberto
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Associate Professor
Chemistry
University of Houston
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Email
(713) 743-1760
Website
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Polymer and organic ultrathin films. We investigate the design and synthesis of organic macromolecules and oligomers capable of controlled-assembly or self-organization as ultrathin films. This includes functional amphiphile synthesis, polymerization on surfaces, network formation, and preparation of ð-electron conjugated polymers.
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Annapragada, Ananth
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Associate Professor
School of Health Information Sciences
UT Health Science Center at Houston
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Email
713-500-3982
Website
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Targeted drug delivery; computational methods in biomedicine. My research interests are in the area of novel drug delivery systems and MEMS technology applied to drug delivery. Current projects include the development of engineered porous particles for aerosol drug delivery, the simulation of particle flow in pulmonary airways, and targeted drug delivery.
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Barry, Michael
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Associate Professor
Molecular and Human Genetics, Immunology
Baylor College of Medicine
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Email
713-798-5959
Department
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We are interested in testing the ability of genetic vaccines to combat pathogens that have evolved to escape the immune system. To do this, we are taking advantage of the fact that genetic vaccines are simple plasmids and that these can be easily manipulated by recombinant techniques to improve the immunogenicity of vaccine antigens.
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Bittner, Eric
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Associate Professor
Chemistry
University of Houston
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Email
(713) 743-2775
Website
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Theoretical chemical physics. My research in the area of quantum dynamics is primarily focused upon understanding how motions in the condensed phase influence the dynamics of an imbedded quantum mechanical system.
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Blaney, Susan
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Associate Professor
Pediatrics-Hema & Oncology
Baylor College of Medicine
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Email
832-822-1482
BlaneyHome Page
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Neuro-Oncology and Clinical Pharmacology Programs. A primary focus of my research is the development of new drugs for the treatment of central nervous system tumors in children with a particular emphasis on the development of new agents for intrathecal administration.
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Briggs, James
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Associate Professor
Biology and Biochemistry
University of Houston
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Email
713-743-8366
Website
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Computational studies of protein structure and function; Our research is focused on computational studies of protein structure and function, inhibitor design, investigations of possible inhibitor resistance pathways, and development of methods for the above project areas. Targets for these studies include those important in the treatment of AIDS, cancer, bacterial infections, and other disease states. In addition, we work on inhibitors to aid in biowarfare defense (botulinum neurotoxins, anthrax toxin).
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Brinkley, William (Bill)
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VP Dean Of Grad Sch
Corporate Officers-Molecular and Celular Biology
Baylor College of Medicine
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Email
713-798-5263
Website
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We seek to understand the molecular basis of errors and defects in the nucleus and mitotic apparatus (MA) that cause aneuploidy. Our research utilizes molecular biology and genetic approaches combined with digital image analysis at the light and electron microscopy levels to analyze normal and defective features of chromosome condensation, attachment and alignment on the spindle and movements during mitosis in normal and neoplastic cells.
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Brownell, William
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Professor
Otorhinolaryngology
Baylor College of Medicine
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Email
713-798-8540
Website
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Fundamental mechanisms of hearing and biophysics of electromobility
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Cai, Chengzhi
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Assistant Professor
Chemistry
University of Houston
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Email
(713) 743-2710
Website
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supramolecular nanostructures
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Chiu, Wah
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6985
Website
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Structural and Computational Biology of Biological Machines; Biological applications include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Dr. Chiu has been a leading investigator in the development of electron cryomicroscopy to solve structures of macromolecular assemblies at increasingly high resolutions. Computationally, his group has developed single particle reconstruction software, which has been widely adopted by other investigators. He directs an NIH supported center (http://ncmi.bcm.edu). Among many structures his group has done, Chiu is pursuing the structural studies of viruses including herpes simplex virus, bacteriophages andVenezuelan equine encephalitis virus. His approach includes single particle and tomographic electron cryomicroscopy.
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Clementi , Cecilia
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Associate Professor
Chemistry
Rice University
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Email
713-348-3485
Website
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Theory of protein Folding; computational molecular biology
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Colvin, Vicki L.
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Professor/Executive Director, CBEN
Chemistry
Rice University
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Email
713-348-5741
Website
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Nanocrystals and photonic band gap materials
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Conneely, Orla M.
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Ph.D
Molecular and Cellular Biology
Baylor College of Medicine
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Email
713-798-6233
Website
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Deem , Michael W.
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John W. Cox Professor
Bioengineering
Rice University
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Email
713-348-5852
Website
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Vaccine design; physical theories of pathogen evolution and the immune response; Newton's laws of biology.
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Dessauer, Carmen
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Associate Professor
Medical School
UT Health Science Center at Houston
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Email
713-500-6308
Website
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Structural, biochemical, and molecular biology techniques; Dynamics of cAMP production by signaling complexes at the plasma membrane
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Dickinson, Mary
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Assistant Professor
Molec.Physiology
Baylor College of Medicine
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Email
713-798-2104
Website
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My laboratory uses a multi-disciplinary approach to study the role of fluid-derived mechanical forces in vascular remodeling and heart morphogenesis in early vertebrate embryos. We have recently developed methods for time-lapse, confocal imaging of rapid blood flow and heart mechanics using vital fluorescent protein reporters. With these methods we are studying the response to changes in mechanical stress in mouse and zebrafish models, taking advantage of the wealth of mutant animals.
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Diehl, Michael
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Assistant Professor
Bioengineering
Rice University
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Email
713-348-4568
Website
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Biomotor Cooperativity, Biomaterial, Supramolecular Biophysics, Molecular Bioengineering
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Drezek, Rebekah A.
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Professor
Bioengineering
Rice University
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Email
713-348-3011
Website
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Nanotechnology; molecular imaging; biophotonics
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Estes, Mary K.
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Professor
Virology & Microbiology
Baylor College of Medicine
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Email
713-798-3585
Website
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Molecular biology and structure of virus assembly; multidisciplinary approaches to probe the structure and molecular biology of GI viruses to understand the basic mechanisms that control virus replication, morphogenesis, virus-host interactions, and pathogenesis.
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Ethun, Karen
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Executive Director, Keck Center
GCC/Keck Center
Gulf Coast Consortia
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Email
713-348-4753
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GCC/Keck Center Programs
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Fang, Bingliang
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Thoracic and Cardiovascular Surgery
UT M. D. Anderson Cancer Center
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Email
713-794-4039
Website
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Special interests in drug discovery and development, cancer biology and tumor targeting.
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Fox , Robert O.
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Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
409-772-2163
Website
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Our laboratory investigates the structural basis of macromolecular interactions using a variety of biophysical tools including X-ray crystallography and NMR spectroscopy. The general goal of our laboratory is to determine the manner in which amino acid sequence information promotes the formation of stable folded globular protein molecules and modulates the affinity and specificity of protein ligand interactions. We use molecular genetic tools to produce variant protein molecules for characterization by biophysical methods.
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Gao, Xiaolian
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Professor
Chemistry
University of Houston
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Email
713-743-2805
Website
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Biophysical and organic chemistry; Research in the laboratory is at the interfaces of chemistry and biological sciences. Our work focuses on two areas: (1) Biological NMR of nucleic acids, proteins, and their complexes with ligand molecules. (2) Microarray BIOCHIP technologies in synthesis and applications.
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Glueck, Melissa
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Administrative Program Director
Keck Center
Gulf Coast Consortia
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Email
713-348-4563
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Melissa manages the following GCC/Keck Center Training Programs: AHRQ Patient Safety and Quality, Computational and Structural Biology in Biodefense (CSBB), Keck Virus Imaging, Nanobiology, Pharmacoinformatics, and NLM.
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Gorenstein, David G.
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Professor and Deputy Director
The Brown Foundation Institute of Molecular Medicine
UT Health Science Center at Houston
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Email
713-500-2408
Website
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Proteomics and nanomedicine for both diagnostics and therapeutics in both infectious diseases and cancer; structural biology, drug design, nucleic acid and protein chemistry
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Grande-Allen, K. Jane
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Associate Professor
Bioengineering
Rice University
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Email
713-348-3704
Website
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Work in my laboratory uses the engineering analysis of tissue composition and behavior to investigate tissue and cellular responses to disease, using the cardiac valves as a paradigm for other soft tissues. My research interests include: integrative biomechanics, biochemistry, pathology, & therapies of heart valve disease; extracellular matrix; proteoglycans, organ cultured & tissue engineered surrogates for studies of soft tissue biology & disease.
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Hafner, Jason
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Associate Professor
Physics and Astronomy
Rice University
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Email
713-348-3205
Website
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Nanometer-scale tools to study biological systems
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Halas, Naomi
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Stanley C. Moore Professor
Elec & Comp Engineering
Rice University
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Email
713-348-5611
Website
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Development of nanoscale tools and devices for intracellular sensing, spectroscopy and detection of biomolecules, and applications in cancer diagonostics and therapeutics
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Hartgerink, Jeffery Dale
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Associate Professor
Chemistry
Rice University
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Email
713-348-4142
Website
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Supramolecular chemistry
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Hauge, Robert H.
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Chemistry
Rice University
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Email
(713) 348-6384
Website
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Physical, inorganic and materials chemistry
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He, Xiangwei
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Assistant Professor
Mol. & Human Gen
Baylor College of Medicine
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Email
713-798-2093
Website
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Chromosome Segregation: Interaction Between Spindle and Kinetochores. Research in my laboratory aims at a specific aspect of chromosome segregation, namely, how the proper interaction between spindle microtubules and kinetochores is established and maintained. Our model organism is the fission yeast, Schizosacchromyces pombe. Our short term goal is to dissect the protein composition of the kinetochore in fission yeast to provide the structural basis for functional study. Using genetic approaches, we isolated mutants that specifically disrupt kinetochore functions. We also take the biochemical approach to purify and analyze kinetochore proteins that are of minute amount in the cell.
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Herzog, Norbert K.
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Professor and Assistant Dean, GSBS; Member Faculty, WHO Collaborating Center for Tropical Diseases
Department of Pathology
UT Medical Branch at Galveston
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Email
409-772-2618 /
Website
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My laboratory is engaged in research into the processes of cellular signal transduction and their role in disease pathogenesis. I study the role of cellular transcription factors in normal cellular signal transduction in an effort to understand how alterations in these systems lead to or contribute to diseases such as cancer and infectious diseases. Lassa Fever, and many other hemorrhagic fever viruses as well as West Nile virus are on the select list of bioterrorist threat agents.
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Johnsson, Lennart
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Cullen Distinguished Professor
Computer Sciences
University of Houston
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Email
713-743-3371
Website
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Computational and data grids
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Kakadiaris, Ioannis
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Professor
Computer Science
University of Houston
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Email
713-743-1255
Website
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Biomedical image analysis, modeling, and simulation; Computational biomedicine; Computer vision; Pattern recognition
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Kavraki , Lydia
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Noah Harding Professor of Computer Science & Professor of Bioengineering
Computer Science and Bioengineering
Rice University
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Email
713-348-5737
Website
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Kavraki's group develops computational tools on high-performance systems to model protein structure and function, understand biomolecular interactions and help analyze, in the long run, the molecular machinery of the cell. This is done by integrating sequence information with three-dimensional structural information to capture, represent and exploit relevant molecular motion. Of particular interest are the identification of three-dimensional functional motifs in protein databases, docking of flexible molecules to flexible receptors, computer-assisted drug discovery, and the understanding and compact representation of structural changes in large biomolecular machines.
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Kiang, Ching-Hwa
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Assistant Professor
Physics and Astronomy
Rice University
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Email
713-348-4130
Website
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Molecular biophysics; soft condensed matter physics
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Killian, Tom
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Associate Professor
Physics and Astronomy
Rice University
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Email
713-348-2927
Website
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Atomic, Molecular, Optical and Plasma Physics: Cold collisions, Bose-Einstein condensation, fundamental measurements, high resolution spectroscopy, atom-photon interactions, and low temperature plasmas; Manipulation of biological systems with magnetic and electric fields.
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Kolomeisky, Anatoly B.
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Associate Professor
Chemistry
Rice University
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Email
713-348-5672
Website
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Theoretical physical chemistry and biophysics
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Li, Renhao
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Assistant Professor
Center for Membrane Biology, Dept of Biochemistry & Molecular Biology
UT Health Science Center at Houston
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Email
713-500-7233
Website
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Molecular regulation and structural basis of transmembrane signaling
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Lichtarge, Olivier
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Professor
Molecular & Human Genetics
Baylor College of Medicine
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Email
713-798-5646
Website
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Protein functional surfaces; assembly of active complexes
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Ludtke, Steve
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Associate Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6989
Website
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My work involves the 3D reconstruction of molecules and macromolecules using a technique called single particle reconstruction. My most significant contribution to the field is the development of the EMAN software package (see below), which performs semi-automated processing of individual molecule images to produce accurate 3D reconstructions.
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Ma , Jianpeng
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Associate Professor
Bioengineering
Rice University
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Email
713-348-5713
Website
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Simulation of supermolecular complexes; computer-aided drug-design. Our group is using combined experimental and computational methods to study the fusion mechanisms of influenza virus, especially the hemagglutinin-mediated cell membrane fusion. Of particular interest is to derive structural information for intermediates along the pH-triggered conformational transition, which is an extremely difficult problem. We will employ a suite of biophysical techniques including various imagining methods and computer simulation techniques.
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MacKenzie , Kevin R
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Assistant Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-2228
Website
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Structure and stability of membrane proteins
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Matthews, Kathleen S
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Stewart Memorial Professor, Biochemistry/Cell Bio
Wiess School of Natural Sciences
Rice University
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Email
713-348-4871
Website
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Structure and function of genetic regulatory proteins
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Mikos, Antonios G.
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J. W. Cox Professor, Director of J. W. Cox Lab for Biomedical Engineering
Bioengineering
Rice University
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Email
(713)348-5355
Website
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Biomaterials; drug delivery; gene therapy; tissue engineering. The synthesis, processing, and evaluation of new biomaterials for tissue engineering, scaffolds for three-dimensional cell culture, conduits for guided tissue regeneration, substrates for targeted cell adhesion, carriers for controlled drug delivery, and non-viral vectors for gene therapy. We are also developing new CAD/CAM and polymer chemistry fabrication technologies for the production of synthetic biomimetic materials that exhibit the mechanical responsiveness and biochemical processing capabilities of living cells and tissues.
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Mittleman, Daniel M.
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Associate Professor
Elec & Comp Engineering
Rice University
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Email
713-348-5452
Website
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THz spectroscopy and imaging; Photonic crystals; Our current research involves the generation and detection of sub-picosecond pulses of far-infrared radiation.
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Nikonowicz, Edward
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Associate Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-4912
Website
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RNA-Protein biochemistry, structure-function relationships in nucleic acid systems; In addition to NMR spectroscopy, we use biochemical, computational, and optical methods to investigate the kinetic, motional, and structural properties of the component molecules; The interaction of primary ribosomal proteins with their RNA targets; Post-transcriptional modification of tRNA.
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O'Malley, Bert W.
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Chairman/Professor
Academic Department
Baylor College of Medicine
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Email
713-798-6205
Department
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Regulation of eucaryotic gene expression; cell- and gene-specific transcriptional regulators.
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Osborne, C. Kent
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Professor
Breast Cancer
Baylor College of Medicine
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Email
713-798-1641
Home Page
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The molecular mechanisms for hormonal resistance in breast cancer focusing on crosstalks with growth factor signaling pathways, phosphorylation of estrogen receptor, and interaction with receptor coregulators.
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Palzkill, Timothy
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Chair and Professor
Pharmacology
Baylor College of Medicine
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Email
713-798-5609
Website
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Molecular Basis of Antibiotic Resistance, Functional Genomics of Bacterial Pathogens
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Pasquali, Matteo
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Associate Professor
Chemical & Biomolecular Engineering
Rice University
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Email
713-348-5830
Website
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The interaction of flow and liquid micro- and nano-structure; Microstructured liquids; Computational modeling of processing flows; Free surface flows; Visualization of flowing single DNA molecules; Rheology and phase behavior of Single-Walled Carbon Nanotubes; Rheology and microstructure of Polymeric Nanoparticles (particoils); Rheology and microstructure of Emulsions; Single-molecule behavior of semiflexible macromolecules.
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Pati, Debananda
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Assistant Professor
Pediatric Hematology/Oncology
Baylor College of Medicine
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Email
832-824-4575
Website
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My laboratory is interested in identifying proteins that coordinate aneuploidy, cell division, and apoptosis in cancer tissues in an effort to understand the regulatory network that assures accuracy of chromosomal separation in dividing cells. Premature or erroneous separation of sister chromatids or homologous chromosomes can result in birth defects or inherited genetic diseases, including cancer. My research is aimed at elucidating the molecular mechanism of chromosomal instability through analysis of the factors that mediate sister chromatid cohesion and separation during mitosis. To characterize the molecular interactions of cohesin subunit with chromatids and other nuclear proteins and to visualize the cohesin structures and topology on the chromosomes, we intend to utilize nanobiology reagents.
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Pettitt, B. Monte
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Cullen Distinguished Professor
Chemistry
University of Houston
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Email
713-743-3263
Website
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Chemical physics; Physical chemistry; Biochemistry; Computer Science; Development of methods for calculating internal conformational structure and interpreting conformational equilibria of biomolecular solutes in aqueous environments; Structural and thermodynamic description of neat polar molecular fluids, including water, ions, polar biomolecular solutes and other condensed phase systems via integral equation and density functional methods; Development of theoretical techniques for the description of the thermodynamics and structure of ionic and anisotropic fluids; Development of methods to compare and search genomes
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Poplack, David
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Professor
Pediatrics-Hema & Oncology
Baylor College of Medicine
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Email
832-822-4556
Baylor Home Page
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Prasad, B.V.
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-5686
Website
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Structure-function relationships in medically important viruses. Three-dimensional structural analyses on viruses that are causative agents of endemic severe diarrhea in humans. These viruses include rotavirus, calicivirus, and Norwalk virus.
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Putkey, John
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Professor
Medical School
UT Health Science Center at Houston
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Email
713-500-6061
Website
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My laboratory applies a synergistic blend of molecular and structural biology to study the molecular anatomy of calcium binding proteins; The mechanisms of regulation of calmodulin activity by post-translational modification and modulation of calmodulin binding to target proteins; Exploring the molecular mechanism of regulation of cardiac muscle contraction by calcium binding to cardiac troponin C, and how cardiotonic drugs lead to an increased efficiency of cardiac muscle contraction; Using NMR to reveal the strucutral basis behind why mutations in the extracelluar matix protein COMP lead to skeletal dysplasias and dwarfing syndromes.
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Raphael, Robert
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Associate Professor
Bioengineering
Rice University
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Email
713-348-3494
Website
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Cell Mechanics, Electromechanical Transduction in Cochlear Outer Hair Cells and Soft Materials, Theoretical Modeling of Biological Systems, Biophysical Factors Mediating Gene Delivery, Aspirin-Like Molecules and Membrane Mechanics
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Richards-Kortum, Rebecca
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Stanley C. Moore Professor Professor and Department Chair
Bioengineering
Rice University
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Email
713-348-3823
Website
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Her research centers on new, non-invasive cancer detection technologies that use high-resolution, optical imaging; the use of fluorescent imaging agents for cancer detection; biophysical studies of the light-scattering properties of cells and tissues; and the use of fiber-optic sensors for in vivo detection of cancer
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Saggau, Peter
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Professor
Division Of Neuroscience
Baylor College of Medicine
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Email
713-798-5082
Website
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Modulation of synaptic transmission; The research interests in our lab are twofold: to understand the biophysics of central mammalian neurons that control both the communication between cells and their individual computational properties, and to develop advanced optical imaging tools for studying living brain tissue that help us to achieve this goal.
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Scuseria, Gustavo E
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Robert A. Welch Professor
Chemistry
Rice University
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Email
713-348-4746
Website
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Theoretical chemistry, ab initio computational quantum chemistry, density functional theory, development of new methods for molecular electronic structure, and applications to nanostructures.
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Shamoo , Yousif
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Associate Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-5493
Website
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sequence-specic RNA recognition, DNA replication and molecular evolution of microbial populations
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Sorensen , Danny C
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Noah Harding Professor; Department Chair
Comp & Applied Mathematics
Rice University
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Email
713-348-5193
Website
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Numerical Linear Algebra, Numerical Analysis, Model Order Reduction, Control of Dynamical Systems, Numerical Optimization, Parallel Numerical Algorithms.
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Tao, Yizhi
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Assistant Professor
Biochemistry &Cell Biology
Rice University
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Email
713-348-4910
Website
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Regulation of virus genome replication; molecular mechanism of eukaryotic chromosome condensation. Influenza viruses cause highly contagious, acute respiratory illnesses which have inflicted humans since ancient times. Today influenza remains as a major concern of public health with frequent threat for widespread epidemics. Replication and expression of virus genome are crucial parts of the virus life cycle. Influenza virus RNA transcription is initiated using a capped RNA primer snatched from host mRNAs, whereas RNA replication does not require any primer and hence the replication products are not capped. Four viral proteins are needed for influenza virus RNA synthesis, including the three viral polymerase proteins PA, PB1 and PB2, and the viral nucleoprotein. Our laboratory uses the electron microscopy and three-dimensional reconstruction method to elucidate how influenza virus polymerase, the nucleoprotein, the viral RNA, and other essential components coordinate their functions to ensure both cap-dependent and cap-independent RNA synthesis. In particular, the structures of various polymerase-RNA complexes will be studied to characterize the transient molecular interactions. Detailed mechanistic studies of influenza virus polymerase will uncover fundamental rules underlying the unique gene expression and replication process shared by segmented, negative-strand and ambi-sense RNA viruses. New antiviral drugs can be designed against the polymerases of these viruses, targeting a few of their virus-specific activities.
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Trautner, Barbara
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Assistant Professor
Internal Medicine - Infectious Diseases
Baylor College of Medicine
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Email
713-798-4264
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Prevention of catheter-related urinary tract infections
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Tsai, Francis
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Associate Professor
Biochemistry & Molecular Biology
Baylor College of Medicine
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Email
713-798-8668
Website
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Structure and function of macromolecular complexes and supramolecular assemblies involved in protein folding, transcriptional regulation and cellular signaling.
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Tweardy, David J.
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Professor
Medicine-Infectious Diseases
Baylor College of Medicine
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Email
713-798-8918
Website
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signal transduction events activated in normal and leukemic human myeloid cells by granulocyte colony stimulating factor and other inflammatory mediators; the impact of trauma and shock on host susceptibility to hospital-acquired infections and the role of the inflammatory response in infection.
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Vekilov, Peter
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Associate Professor
Chemical Engineering
University of Houston
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Email
713-743-4315
Website
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Protein crystallization; physico-chemical aspects of sickle-cell anemia; kinetics and stability of crystal growth; Nucleation and phase transitions in protein solutions; Protein intermolecular interactions and phase diagrams; Crystallization of membrane proteins
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Waxham, Neal
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Professor
Neurobiology & Anatomy
UT Health Science Center at Houston
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Email
713.500.5621
Website
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synaptic plasticity and transmission in the mammalian CNS
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Weisman, R. Bruce
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Professor
Chemistry
Rice University
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Email
713-348-3709
Website
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Molecular photochemistry; photophysics of fullerenes and carbon nanotubes
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West, Jennifer L.
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Professor; Director, Inst of Biosciences & Bioengr
Bioengineering
Rice University
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Email
713-348-5955
Website
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Bioactive and biomimetic biomaterials; tissume engineering; nanotechnology; gene therapy; drug delivery
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Willson, Richard
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Professor
Chemical and Biomolecular Engineering
University of Houston
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Email
713-743-4308
Website
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Biomolecular recognition and its applications in separations and molecular diagnostics; the structural determinants of molecular recognition in complexes of proteins with recognition agents such as monoclonal antibodies and aptamers. Our primary techniques are expression, mutagenesis, fluorescence anisotropy (kinetics) and titration calorimetry.
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Wilson, Lon J.
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Professor
Chemistry
Rice University
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Email
713-348-3476
Website
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Metal ions in biological processes and their use in medicine
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Wong, Michael Sha-Nang
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Associate Professor
Chemical & Biomolecular Engineering
Rice University
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Email
(713) 348-3511
Website
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Nanotechnology and materials chemistry; Nanoparticle Assembly
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Zechiedrich, E. Lynn
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AssociateProfessor
Molecular Virology & Microbiology
Baylor College of Medicine
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Email
713-798-5126
Website
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DNA topoisomererases and antimicrobial resistance
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