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GCC Membrane Biology Directory
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Altenberg, Guillermo
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Assistant Professor
Physiology and Biophysics
UT Medical Branch at Galveston
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Email
409-772-3026
Website
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The focus of the work in my laboratory is the structure and function of membrane transport proteins. We study the structure, transport function and regulation of proteins of the ATP-binding cassette (ABC) superfamily such as P-glycoprotein, CFTR and MRP1. We also have a project on the structural bases for the regulation of connexins, the proteins that form the gap junctions. In addition, we are developing new sensors for glucose and calcium based on the use of specific glucose- and calcium-binding proteins fused to autofluorescent proteins (green fluorescent protein family).
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Bond, Richard A.
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Associate Professor
Pharmacology
University of Houston
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Email
713-743-1210
Website
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Pharmacology of receptor theory, Characterization and classification of G protein-coupled receptors
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Brennan, Richard G.
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Professor
Biochemistry & Molecular Biology
UT M. D. Anderson Cancer Center
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Email
(713) 834-6390
Website
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Multidrug resistance, protein-nucleic interaction, regulation of gene expression; oxidative stress responses; protein-ligand interaction, toxin-antitoxin structure and function; macromolecular crystallography
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Brownell, William
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Professor
Otorhinolaryngology
Baylor College of Medicine
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Email
713-798-8540
Website
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Fundamental mechanisms of hearing and biophysics of electromobility
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Chiu, Wah
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6985
Website
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Structural and Computational Biology of Biological Machines; Biological applications include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Dr. Chiu has been a leading investigator in the development of electron cryomicroscopy to solve structures of macromolecular assemblies at increasingly high resolutions. Computationally, his group has developed single particle reconstruction software, which has been widely adopted by other investigators. He directs an NIH supported center (http://ncmi.bcm.edu). Among many structures his group has done, Chiu is pursuing the structural studies of viruses including herpes simplex virus, bacteriophages andVenezuelan equine encephalitis virus. His approach includes single particle and tomographic electron cryomicroscopy.
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Chow , Dar-chone
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Assistant Professor
Chemistry
University of Houston
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Email
713-743-1798
Website
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One research goal in our laboratory is to understand the basis of conformational changes in the function of a protein.
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Christie, Peter
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Professor
Medical School
UT Health Science Center at Houston
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Email
713-500-5440
Website
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macromolecular transport processes during pathogenesis
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Delcour, Anne
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Professor
Biology and Biochemistry
University of Houston
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Email
713-743-2684
Website
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molecular mechanisms of ion channel function and modulation
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Dessauer, Carmen
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Associate Professor
Medical School
UT Health Science Center at Houston
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Email
713-500-6308
Website
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Structural, biochemical, and molecular biology techniques; Dynamics of cAMP production by signaling complexes at the plasma membrane
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Dowhan, William
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Professor
Biochemistry and Molecular Biology
UT Health Science Center at Houston
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Email
713-500-6051
Website
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Structure, function and assembly of cell membranes
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Du, Guangwei
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Assistant Professor
Integrative Biology and Pharmacology
UT Health Science Center at Houston
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Email
Website
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Phospholipid Signaling and Metabolism in Human Disease
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Farrell, Brenda
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Assistant Professor
Otorhinolaryngology
Baylor College of Medicine
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Email
713-798-8541
Website
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Fox , Robert O.
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Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
409-772-2163
Website
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Our laboratory investigates the structural basis of macromolecular interactions using a variety of biophysical tools including X-ray crystallography and NMR spectroscopy. The general goal of our laboratory is to determine the manner in which amino acid sequence information promotes the formation of stable folded globular protein molecules and modulates the affinity and specificity of protein ligand interactions. We use molecular genetic tools to produce variant protein molecules for characterization by biophysical methods.
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Gustin, Mike
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Associate Professor
Biochemistry and Cell Biology
Rice University
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Email
713-348-5158
Website
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Molecular genetics and biochemistry of signal transduction.
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Hafner, Jason
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Associate Professor
Physics and Astronomy
Rice University
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Email
713-348-3205
Website
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Nanometer-scale tools to study biological systems
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Halas, Naomi
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Stanley C. Moore Professor
Elec & Comp Engineering
Rice University
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Email
713-348-5611
Website
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Development of nanoscale tools and devices for intracellular sensing, spectroscopy and detection of biomolecules, and applications in cancer diagonostics and therapeutics
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Hancock, John
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Professor and Chairman
Integrative Biology and Pharmacology
UT Health Science Center at Houston
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Email
Website
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Plasma Membrane Microstructure and Signal Transduction
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Heidelberger, Ruth
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Assistant Professor
Neurobiology and Anatomy
UT Health Science Center at Houston
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Email
713-500-5624
Website
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Mechanisms Of Neurotransmitter Release
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Higgins, Catherine
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Research Consortia
Gulf Coast Consortia
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Email
713-348-4772
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Hirschi, Kendal
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Associate Professor
Pediatrics Nutrition
Baylor College of Medicine
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Email
713-798-7011
Website
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Plant Ion Homeostasis
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Horrigan, Frank
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Associate Professor
Molecular Physiology and Biophysics
Baylor College of Medicine
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Email
Website
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Mechanisms that govern the opening and closing (gating) of ion channels
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Huang, Huey
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Sam & Helen Worden Professor
Physics and Astronomy
Rice University
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Email
713-348-4899
Website
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membrane-membrane interactions (fusions) and protein-membrane interactions
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Hyser, Joseph
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Postdoctoral fellow; Mary Estes lab
Department of Molecular Virology and Microbiology
Baylor College of Medicine
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Email
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Structure/Funcation studies of the pore-forming domain of rotavirus NSP4
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Jayaraman, Vasanthi
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Associate Professor
Center for Membrane Biology, Dept of Biochemistry & Molecular Biology
UT Health Science Center at Houston
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Email
713-500-6236
Website
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Structure and function; membrane bound proteins; ion channels
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Kaplan, Heidi
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Associate Professor
Microbiology and Molecular Gen
UT Health Science Center at Houston
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Email
713-500-5448
Website
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cell-cell interactions required for multicellular development and biofilm formation
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Kunz, Jeannette
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Assistant Professor
Molec. Physiology Kunz
Baylor College of Medicine
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Email
713-798-5797
Website
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the role of the lipid second messenger phosphatidylinositol-4,5-bisphosphate (PI4,5P2) in eucaryotic cells
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Li, Renhao
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Assistant Professor
Center for Membrane Biology, Dept of Biochemistry & Molecular Biology
UT Health Science Center at Houston
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Email
713-500-7233
Website
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Molecular regulation and structural basis of transmembrane signaling
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Ludtke, Steve
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Associate Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6989
Website
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My work involves the 3D reconstruction of molecules and macromolecules using a technique called single particle reconstruction. My most significant contribution to the field is the development of the EMAN software package (see below), which performs semi-automated processing of individual molecule images to produce accurate 3D reconstructions.
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Ma, Qing
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Assistant Professor
Blood and Marrow Transplantation Center for Cancer Immunology Research
UT M. D. Anderson Cancer Center
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Email
713-563-3327
Website
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Ma , Jianpeng
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Associate Professor
Bioengineering
Rice University
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Email
713-348-5713
Website
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Simulation of supermolecular complexes; computer-aided drug-design. Our group is using combined experimental and computational methods to study the fusion mechanisms of influenza virus, especially the hemagglutinin-mediated cell membrane fusion. Of particular interest is to derive structural information for intermediates along the pH-triggered conformational transition, which is an extremely difficult problem. We will employ a suite of biophysical techniques including various imagining methods and computer simulation techniques.
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MacKenzie , Kevin R
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Assistant Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-2228
Website
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Structure and stability of membrane proteins
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Margolin, William
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Professor
Microbiology and Molecular Genetics
UT Health Science Center at Houston
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Email
(713)-500-5452
Website
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targeting and assembly of the bacterial cell division complex
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Mayer, Andreas
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Professor
Biochemistry and Molecular Biology
Baylor College of Medicine
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Email
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McNew, James
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Assistant Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-3133
Website
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Molecular mechanism of biological membrane fusion. We use biochemistry, cell biology and molecular genetic techniques to study membrane fusion in two major model systems: vesicular transport in the budding yeast S. cerevisiae and neurosecretion in the fruitfly D. melanogaster. A primary focus of the lab is the functional reconstitution of exocytosis in the yeast. Another focus of the lab is the regulation of neuroscretion. We use our in vitro reconstituted fusion system containing SNARE proteins from Drosophila to examine neuronal specific regulatory factors.
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Navarro, Javier
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Professor
Neuroscience and Cell Biology
UT Medical Branch at Galveston
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Email
409-772-5480
Website
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The molecular mechanism of G protein-coupled receptors; Applying X-ray crystallography to elucidate the atomic structure of seven-helix transmembrane receptors; Genetic and biophysical approaches to determine the role of specific domains.
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Oberhauser , Andres
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Associate Professor
Neuroscience and Cell Biology
UT Medical Branch at Galveston
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Email
409-772-1309
Website
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Protein folding and protein mechanics; The mechanism by which proteins respond to mechanical forces. Currently we are studying the mechanical properties of the cell matrix protein perlecan (an abundant component of the basal lamina), polycystin-1 (a cell membrane receptor) and projectin (a protein found in insect flight muscles).
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Oghalai, John S.
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Assistant Professor
Otorhinolaryngology
Baylor College of Medicine
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Email
713-798-5118
Website
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Otology (chronic otitis media, cholesteatoma, otosclerosis, and conductive hearing loss), Neurotology (cochlear implantation, inner ear disease, and facial nerve disorders), and Skull Base Surgery (acoustic neuroma, meningiomas, glomus jugulare tumors, temporal bone and other skull base tumors)
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Palmer , Graham A
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Professor Emeritus
Biochemistry & Cell Biology
Rice University
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Email
713-348-4860
Website
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Mechanisms of oxidase enzymes
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Pedemonte, Carlos H.
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Professor
Pharmacology
University of Houston
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Email
713-743-1211/12
Website
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Sodium reabsorption in the kidney; sodium pump in hypertension; Function-structure relationship of the sodium pump.
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Pedersen, Steen
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Associate Professor
Molec. Physiology Pederson
Baylor College of Medicine
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Email
713-798-3888
Website
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Allosteric mechanisms of ion channel function. Current research efforts in the lab comprise three general areas: structure-activity of ligand binding, kinetic analysis of conformational transitions, and determination of structural changes upon binding and conformational changes.
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Pereira, Frederick A.
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Assistant Professor
Huffington Center On Aging
Baylor College of Medicine
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Email
713-798-6933
Website
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Aging and Regeneration of the hearing and balance systems
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Peters, Christopher
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Assistant Professor
Biochemistry and Molecular Biology
Baylor College of Medicine
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Email
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Quiocho, Florante
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Professor
Hhmi Biochemistry
Baylor College of Medicine
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Email
713-798-6565
Website
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Structural Biophysics and Biology; X-Ray Crystallography of Proteins; Molecular Recognition and Protein-Ligand Interactions. Our research interest is centered on the study of the tertiary structure and function of proteins and enzymes at atomic resolution.
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Raphael, Robert
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Associate Professor
Bioengineering
Rice University
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Email
713-348-3494
Website
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Cell Mechanics, Electromechanical Transduction in Cochlear Outer Hair Cells and Soft Materials, Theoretical Modeling of Biological Systems, Biophysical Factors Mediating Gene Delivery, Aspirin-Like Molecules and Membrane Mechanics
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Ridge, Kevin
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Associate Professor
Center for Membrane Biology, Dept of Biochemistry & Molecular Biology
UT Health Science Center at Houston
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Email
(713) 500-5908
Website
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Dynamic aspects of integral membrane protein structure, development and application of general approaches for the large-scale expression and purification of GPCR's
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Saggau, Peter
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Professor
Division Of Neuroscience
Baylor College of Medicine
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Email
713-798-5082
Website
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Modulation of synaptic transmission; The research interests in our lab are twofold: to understand the biophysics of central mammalian neurons that control both the communication between cells and their individual computational properties, and to develop advanced optical imaging tools for studying living brain tissue that help us to achieve this goal.
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Schroit, Alan
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Professor
Cancer Biology
UT M. D. Anderson Cancer Center
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Email
713-792-8586
Website
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The mechanism by which cells control the transbilayer distribution of phospholipids between the bilayer leaflet and the machinery responsible for the pathologic redistribution of phospholipids in different cell types
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Sifers, Richard
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Associate Professor
Pathology
Baylor College of Medicine
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Email
713-798-3169
Website
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Cellular Glycobiology, Conformational Disease, Glycoprotein Folding, Quality Control, Oligosaccharides, Endoplasmic Reticulum, Conformational Disease, alpha1-Antitrypsin Deficiency, Glycobiology
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Spudich, John
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Professor/ R. Welch Dist Chr in Chemistry
Center for Membrane Biology, Dept of Biochemistry & Molecular Biology
UT Health Science Center at Houston
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Email
713-500-5473
Website
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Structure and function of photoactive membrane receptors and signal transduction triggered by light; rhodopsins and related heptahelical receptors.
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Strobel, Henry
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Professor/Assoc. Dean Faculty Affairs/Asst. Dean Student Affairs
Medical School
UT Health Science Center at Houston
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Email
713-500-6078
Website
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Gene expression, Gender-Specific CYP3A Expression in Rodents, Identification and Characterization of Novel CYP3As in Primates
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Wensel, Theodore G
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-6994
Website
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Structure and Dynamics of Signal Transducing Membranes
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Zechiedrich, E. Lynn
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AssociateProfessor
Molecular Virology & Microbiology
Baylor College of Medicine
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Email
713-798-5126
Website
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DNA topoisomererases and antimicrobial resistance
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Zheng, Lei
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Assistant Professor
Center for Membrane Biology, Dept of Biochemistry & Molecular Biology
UT Health Science Center at Houston
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Email
713-500-6083
Website
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Maintaining ion homeostasis across the cell membrane is fundamental to normal cell function. The research of our lab focuses on structure, function and regulation of ion transport proteins by using a combination of biochemical and biophysical approaches, primarily X-ray crystallography.
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