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GCC Protein Crystallography Directory
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Bellamy, Henry
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Associate Professor Research/PX Beamline Manager
J. Bennett Johnston, Sr., Center for Advanced Microstructures and Devices (CAMD)
Louisiana State University
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Email
225-578-9342
Website
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Brennan, Richard G.
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Professor
Biochemistry & Molecular Biology
UT M. D. Anderson Cancer Center
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Email
(713) 834-6390
Website
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Multidrug resistance, protein-nucleic interaction, regulation of gene expression; oxidative stress responses; protein-ligand interaction, toxin-antitoxin structure and function; macromolecular crystallography
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Chen, Xiaomin
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Assistant Professor
Biochemistry & Molecular Biology
UT M. D. Anderson Cancer Center
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Email
713-834-6279
Website
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X-ray crystallography, macromolecular interactions, signal transduction, transcription regulation, apoptosis
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Cheng, Xiaodong
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Associate Professor
Pharmacology
UT Medical Branch at Galveston
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Email
409-772-9656
Website
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Mitogen-activated protein kinases
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Choi, Kay
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Assistant Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
(409) 747-1402
Website
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Our research focuses on the structure and mechanism of viral replication and infection machinery using X-ray crystallography and cryo-electron microscopy. High-resolution X-ray crystal structures of individual component proteins can be fitted into lower resolution cryo-EM density maps to generate pseudo-atomic structure of large macromolecular complexes.
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Chow , Dar-chone
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Assistant Professor
Chemistry
University of Houston
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Email
713-743-1798
Website
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One research goal in our laboratory is to understand the basis of conformational changes in the function of a protein.
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Czerwinski, Edmund
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Human Biological Chemistry & Genetics
UT Medical Branch at Galveston
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Email
409-772-3287
Website
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Davey, Robert
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Assoc Professor
Microbiology and Immunology
UT Medical Branch at Galveston
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Email
409-772-4915
Website
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Our research focuses on how membrane enveloped viruses enter cells. Understanding this event would aid the development of drugs to prevent the cell to cell spread of viruses such as HIV. Research mixes Virology and Structural Biology to dissect the trigger mechanism and the molecular motor that drive the fusion of the viral and cell membranes. We are working on Murine Leukemia Viruses but will soon look at other enveloped viruses that cause human disease; Use of nanoscale technologies to treat human genetic and infectious disease.
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Fox , Robert O.
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Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
409-772-2163
Website
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Our laboratory investigates the structural basis of macromolecular interactions using a variety of biophysical tools including X-ray crystallography and NMR spectroscopy. The general goal of our laboratory is to determine the manner in which amino acid sequence information promotes the formation of stable folded globular protein molecules and modulates the affinity and specificity of protein ligand interactions. We use molecular genetic tools to produce variant protein molecules for characterization by biophysical methods.
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Higgins, Catherine
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Research Consortia
Gulf Coast Consortia
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Email
713-348-4772
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Jacobson, Raymond
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Assistant Professor
Biochemistry & Molecular Biology
UT M. D. Anderson Cancer Center
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Email
713-834-
Website
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Biochemical and 3-Dimensional Structure Analysis of Basal Transcription Proteins/Complexes
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Morais, Marc
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Assistant Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
(409) 747- 1401
Website
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Our work focuses on virus structure and the general principles by which viruses self-assemble. In particular, we are interested in how virus self-assembly strategies can be targeted in the design of anti-viral therapeutics, and how these same strategies might be employed in the construction of nanomachines. We are also interested in the structures of morphologically heterogeneous viruses with low, partial, or no internal symmetry. Finally, we are interested in virus evolution and the viruses which infect the archea.
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Prasad, B.V.
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Professor
Biochemistry
Baylor College of Medicine
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Email
713-798-5686
Website
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Structure-function relationships in medically important viruses. Three-dimensional structural analyses on viruses that are causative agents of endemic severe diarrhea in humans. These viruses include rotavirus, calicivirus, and Norwalk virus.
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Quiocho, Florante
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Professor
Hhmi Biochemistry
Baylor College of Medicine
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Email
713-798-6565
Website
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Structural Biophysics and Biology; X-Ray Crystallography of Proteins; Molecular Recognition and Protein-Ligand Interactions. Our research interest is centered on the study of the tertiary structure and function of proteins and enzymes at atomic resolution.
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Schumacher, Maria A.
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Assistant Professor
Biochemistry & Molecular Biology
UT M. D. Anderson Cancer Center
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Email
(713) 834-6392
Website
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Structural biology; crystallography; DNA partition/segregation; transcription regulation; nucleic acid-binding proteins
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Shamoo , Yousif
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Associate Professor
Biochemistry & Cell Biology
Rice University
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Email
713-348-5493
Website
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sequence-specic RNA recognition, DNA replication and molecular evolution of microbial populations
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Tao, Yizhi
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Assistant Professor
Biochemistry &Cell Biology
Rice University
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Email
713-348-4910
Website
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Regulation of virus genome replication; molecular mechanism of eukaryotic chromosome condensation. Influenza viruses cause highly contagious, acute respiratory illnesses which have inflicted humans since ancient times. Today influenza remains as a major concern of public health with frequent threat for widespread epidemics. Replication and expression of virus genome are crucial parts of the virus life cycle. Influenza virus RNA transcription is initiated using a capped RNA primer snatched from host mRNAs, whereas RNA replication does not require any primer and hence the replication products are not capped. Four viral proteins are needed for influenza virus RNA synthesis, including the three viral polymerase proteins PA, PB1 and PB2, and the viral nucleoprotein. Our laboratory uses the electron microscopy and three-dimensional reconstruction method to elucidate how influenza virus polymerase, the nucleoprotein, the viral RNA, and other essential components coordinate their functions to ensure both cap-dependent and cap-independent RNA synthesis. In particular, the structures of various polymerase-RNA complexes will be studied to characterize the transient molecular interactions. Detailed mechanistic studies of influenza virus polymerase will uncover fundamental rules underlying the unique gene expression and replication process shared by segmented, negative-strand and ambi-sense RNA viruses. New antiviral drugs can be designed against the polymerases of these viruses, targeting a few of their virus-specific activities.
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Tsai, Francis
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Associate Professor
Biochemistry & Molecular Biology
Baylor College of Medicine
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Email
713-798-8668
Website
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Structure and function of macromolecular complexes and supramolecular assemblies involved in protein folding, transcriptional regulation and cellular signaling.
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Watowich, Stanley
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Associate Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
409-747-4749
Website
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Dr. Watowich has long-standing interest in virus structure, function, host-responses to infection, and antiviral drug development. The laboratory has solved the crystal structures of individual non-structural and structural proteins from alphaviruses, and carried out biochemical and biophysical studies of flavivirus and alphavirus proteins. Structures of intact RNA viruses and their assembly mechanisms are studied by electron cryomicroscopy, image reconstruction, and biophysical techniques. Structure-based computational drug discovery, in vitro inhibition assays, and cell- based replication assays are used to develop antiviral agents.
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White, Mark A.
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Assistant Professor
Biochemistry and Molecular Biology
UT Medical Branch at Galveston
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Email
(409) 747-4747
Website
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My research interests are in the areas of computational biophysics and crystallography. Crystallography is a tool for examining diverse structures of genomic proteins. Structural genomics combined with homology and 3D modeling of proteins promises to reveal the relationship between the structure and function of proteins.
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